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Alzheimer's Disease and Related Disorders (MERE)

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2011 by University Hospital, Angers
Sponsor:
Information provided by:
University Hospital, Angers
ClinicalTrials.gov Identifier:
NCT01315704
First received: March 11, 2011
Last updated: March 14, 2011
Last verified: March 2011

March 11, 2011
March 14, 2011
November 2009
November 2017   (final data collection date for primary outcome measure)
Spatiotemporal gait parameters [ Time Frame: baseline ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01315704 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Alzheimer's Disease and Related Disorders
Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers

The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.

Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D.

The objectives of this study are to

  • Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages)
  • To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities
  • To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions
  • To establish a database at Angers University Memory Center.
Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Probability Sample

All patients of the University Memory Center of Angers University Hospital with respect to the eligibility criteria

  • Alzheimer's Disease
  • Gait Apraxia
  • Impaired Cognition
Drug: Drug intervention
before-after interventional (anti-dementia drugs and/or vitamin D) study
Other Name: Anti-dementia drugs and/or vitamin D
  • Group 1
    Patients with Mild Cognitive Impairment
    Intervention: Drug: Drug intervention
  • Group 2
    Patients with Mild Alzheimer's disease or related disorders
    Intervention: Drug: Drug intervention
  • Group 3
    Patients with Moderate Alzheimer's disease or related disorders
    Intervention: Drug: Drug intervention
Beauchet O, Launay CP, Allali G, Watfa G, Gallouj K, Herrmann FR, Annweiler C. Anti-dementia drugs and changes in gait: a pre-post quasi-experimental pilot study. BMC Neurol. 2013 Nov 21;13:184. doi: 10.1186/1471-2377-13-184.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
700
November 2017
November 2017   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • All elderly patients from the University Memory Center of Angers University Hospital.
  • Able to walk without any walking aid on 15 meters
  • Mini-Mental Status Examination score > 10
  • Being affiliated to a social security regime

Exclusion Criteria:

  • Mini-Mental Status Examination score ≤ 10
  • Subject suffering from pre-existing impellent disturbances
  • History of cerebrovascular accident or other cerebro-spinal pathology
  • Poor workmanship of the written or oral French language
  • Use of walking aid such as walking frame with wheels or tricycle.
  • Acute medical or surgical disease in the past 3 months
  • Refusal to participate (or trustworthy person)
  • Near visual acuity < 2/10
Both
Not Provided
Yes
Contact: Cedric ANNWEILER, DM (+33) 241354725 ceannweiler@chu-angers.fr
France
 
NCT01315704
2009-15
No
Cédric ANNWEILER ; MD, Memory Centre of Angers University Hospital
University Hospital, Angers
Not Provided
Principal Investigator: Cedric ANNWEILER, MD Memory Centre of Angers University Hospital
University Hospital, Angers
March 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP