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Serum Magnesium and Vascular Calcification

This study has been completed.
Sponsor:
Information provided by:
Ramathibodi Hospital
ClinicalTrials.gov Identifier:
NCT01293786
First received: February 10, 2011
Last updated: May 25, 2011
Last verified: May 2011

February 10, 2011
May 25, 2011
February 2011
May 2011   (final data collection date for primary outcome measure)
The difference in vascular calcification score between KT and CKD [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01293786 on ClinicalTrials.gov Archive Site
  • The association of serum magnesium with vascular calcification in KT [ Time Frame: Baseline ] [ Designated as safety issue: No ]
  • The association of serum magnesium with vascular calcification in CKD [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Serum Magnesium and Vascular Calcification
Comparison of Vascular Calcification Between Kidney Transplant Recipients and Predialysis Chronic Kidney Disease and Its Association With Serum Magnesium

Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.

Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples Without DNA
Description:

serum

Probability Sample

Kidney transplant recipients and predialysis chronic kidney disease patients from outpatient nephrology clinic of Ramathibodi hospital, Mahidol University

  • Vascular Calcification
  • Chronic Kidney Disease
Not Provided
  • Kidney transplant recipients
  • Chronic kidney disease
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
400
May 2011
May 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • kidney transplant recipients at least 1 year post surgery
  • predialysis chronic kidney disease with serum creatinine > 1.1 mg/dL in female and 1.3 mg/dL in male

Exclusion Criteria:

  • acute kidney injury
  • parathyroidectomy
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Thailand
 
NCT01293786
03-02-2011
No
Sinee Disthabanchong, MD, Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Ramathibodi Hospital
Not Provided
Principal Investigator: Sinee Disthabanchong, MD Ramathibodi Hospital, Mahidol University
Ramathibodi Hospital
May 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP