Triclosan Toothpaste and Third Molar Surgery

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2011 by University of Rochester.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Rochester
ClinicalTrials.gov Identifier:
NCT01292343
First received: February 4, 2011
Last updated: February 7, 2011
Last verified: February 2011

February 4, 2011
February 7, 2011
February 2008
July 2011   (final data collection date for primary outcome measure)
dry socket [ Time Frame: 3 to 7 days ] [ Designated as safety issue: No ]
Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction
Same as current
Complete list of historical versions of study NCT01292343 on ClinicalTrials.gov Archive Site
wound infection [ Time Frame: 3 to 7 days ] [ Designated as safety issue: No ]
Development of tooth extraction wound infection 3 to 7 days after extraction
Same as current
Not Provided
Not Provided
 
Triclosan Toothpaste and Third Molar Surgery
Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Dry Socket
  • Wound Infection
  • Other: Colgate Total Toothpaste
    Toothbrushing with Colgate Total Toothpaste
    Other Names:
    • triclosan
    • dentifrice
  • Other: Colgate Regular Toothpaste
    Toothbrushing with Colgate regular toothpaste
    Other Names:
    • fluoride
    • dentifrice
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
120
December 2011
July 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • must include at least one mandibular third molar with partial or full bony impaction
  • no sign of active pericoronal (around the crown) infections
  • must have not taken antibiotics for any reason in the past 30 days
  • must be healthy and between 18 and 35 years of age
  • must be able to read and sign an informed consent

Exclusion Criteria:

  • Subjects with systemic diseases and pregnant or lactating women
  • Subjects with advanced periodontal diseases or having two or more untreated caries lesions
  • Subjects who cannot read and sign an informed consent
  • Subjects with signs of pericoronal infections
Both
18 Years to 35 Years
Yes
Contact: Yanfang Ren, DDS, MPH 585 2735588 yanfang_ren@urmc.rochester.edu
United States
 
NCT01292343
UREDC3rd
No
Yanfang Ren, PI, University of Rochester Eastman Dental Center
University of Rochester
Not Provided
Principal Investigator: Yanfang Ren, DDS, MPH University of Rochester Eastman Dental Center
University of Rochester
February 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP