The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01285336
First received: January 26, 2011
Last updated: January 27, 2011
Last verified: January 2012

January 26, 2011
January 27, 2011
August 2010
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Complete list of historical versions of study NCT01285336 on ClinicalTrials.gov Archive Site
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The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis.

This study is valuable for the understanding the role of DNA repair system plays in the progression of rheumatoid arthritis and for the development of new therapeutic modality in the future.

Rheumatoid arthritis (RA) is a symmetric polyarticular arthritis that primarily affects the small diarthrodial joints of the hands and feet. In addition to inflammation in the synovium, which is the joint lining, the aggressive front of tissue called pannus invades and destroys local articular structures. The synovium is normally a relatively acellular structure with a delicate intimal lining. RA is also a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. It is known that RA can be considered as a complex genetic disease and many "disease-risk" genes or "disease-protective" genes can be involved. Numerous studies reported the association of IL-6, IL-8 genes with systemic lupus erythematosus (SLE) and the association of HLA-DR gene polymorphisms with RA. In addition, the chronic inflammatory process of RA is mediated through cytokines network, which leads to induce some destructive enzymes, like matrix metalloprotieases, in the cellular synovial tissue of joints. Although RA is a common arthritis with a prevalence of 1% in Taiwan, the pathogenesis is still incompletely studied, especially in DNA repair relative genes.

In this proposal, we would like to perform the following experiments:

  1. Study the associations of the polymorphisms of DNA repair relative genes and the susceptibility to RA;
  2. Study the associations of the copy number variation (CNV) of DNA repair relative genes and the susceptibility to RA;
  3. Functional assay in DNA repair relative genes and compare it with the copy number variation (CNV), genotype and/or haplotype in RA patients; So far, we have analyzed the association between RA and several SNPs of MUTYH in DNA repair systems. We also analyzed the relationship between the SNPs results and RA using the pathological features. These data are helpful to clarify the susceptibility of RA patients with the genotype and/or haplotype in DNA repair system.

This study is valuable for the understanding the role of DNA repair system plays in the progression of rheumatoid arthritis and for the development of new therapeutic modality in the future.

Interventional
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Primary Purpose: Health Services Research
Rheumatoid Arthritis
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Experimental: The genetic and the functional study
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • Participant has sang a consent form.

Exclusion Criteria:

  • Participant is under 18 years old.
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01285336
DMR98-IRB-309-1, NSC99-2314-B-039-005-MY3
Not Provided
Chung-Ming Huang, China Medical University Hospital
China Medical University Hospital
National Science Council, Taiwan
Not Provided
China Medical University Hospital
January 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP