The Correlation Between Lung Cancer Susceptibility, Drug Response and Genetic Polymorphism

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital
ClinicalTrials.gov Identifier:
NCT01280448
First received: January 19, 2011
Last updated: NA
Last verified: January 2011
History: No changes posted

January 19, 2011
January 19, 2011
September 2010
Not Provided
Not Provided
Not Provided
No Changes Posted
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The Correlation Between Lung Cancer Susceptibility, Drug Response and Genetic Polymorphism
The Correlation Between Lung Cancer Susceptibility, Drug Response and Genetic Polymorphism

Lung cancer is the leading cause of cancer deaths in Taiwan. The carcinogen in the environment is a key role in the development of lung cancer, and one of its main resource is tobacco. Activated carcinogens in the organism lead to mutations of crucial oncogenes resulting in tumor development. Genes such as Cytochrome P-450 family, GST (glutathione S-transferase) family, UGT (UDP-Glucuronosyltransferase) family, ERCC-1(excision repair cross-complementing rodent repair deficiency),ERCC-4 and ERCC-5,are encoding antioxidant enzymes or involving in the DNA repair process and the production of some transcription factors. In recent years, many studies have shown the correlation between these genes and the susceptibility of lung cancer. Each gene has a different role in the tumor development pathway. CYP, UGT, GST, NAT2 (N-acetyltransferase 2) and NQO1(NAD(P)H:quinono oxidoreductase 1) involve in the production of antioxidant enzymes. The antioxidant enzymes can detoxificate hydrogen peroxide or defense against oxidative stress. However, the genetic polymorphisms may influence the function of detoxification, which cause the increase in the susceptibility of lung cancer. P53 and MDM2 genes play important roles in the production of tumor-suppression proteins and the regulation of transcription factors, which may regulate the growth and the apoptosis of cell cycle and influence the susceptibility of lug cancer. The polymorphisms in ERCC genes may cause the damage in the DNA repair process which might also cause increase in lung cancer susceptibility. The overexpression of epidermal growth factor receptor is highly correlated with increasing risk of the non-small cell lung cancers. The overexpression may induce the proliferation of cancer cells and the inhibition of the apatosis. Therefore, in recent years, EGFR has been widely studied as the new target of the drugs and the susceptibility of the lung cancer. In addition,the genetic polymorphisms in drug metabolism channel proteins, like OCT2 (organic cation transporter), ATP7A, ATP7B and ABC (ATP-binding cassette) transporter may have influence on the metabolism, the efficacy and the toxicity of the drugs.

The current study is a matched case-control study. The experimental group is the patients diagnosed as lung cancer at Taipei Medical University- Wanfang Hospital from January 2010 to December 2013, and one healthy patient will be matched to each case as the control group. The purpose of the current study is to investigate the association between genetic polymorphisms and lung cancer in the Taiwanese population and to analyze the correlation.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

genes

Non-Probability Sample

Lung Cancer patients

Lung Cancer
Not Provided
  • Case Group
  • Control Group
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
600
September 2013
Not Provided

Inclusion Criteria:

  • This study has two groups, the case group and the control group. The match criteria is patients with the same gender and the age is ± 5 years.

    1. Case group - Patients with the pathology diagnosed as the primary lung cancer patients.
    2. Control group - Patients without any cancer or disease history of cancers.

Exclusion Criteria:

  • Case group - Patients with the pathology diagnosed as the non-primary lung cancer patients or the patients with lung cancer induced by other cancer metastasis.
  • Control group -

    1. With other cancers.
    2. With COPD induced by smoking or the genetic factors.
    3. With familial adenomatous polyposis
    4. With HIV infection, hepatitis B or hepatitis C
Both
20 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01280448
99054
No
Hsingjin Eugene Liu, MD PhD, Department of Hematology-oncology, WanFang Hospital
Taipei Medical University WanFang Hospital
Not Provided
Principal Investigator: Hsin-Gjin Eugene Liu Taipei Medical University WanFang Hospital
Taipei Medical University WanFang Hospital
January 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP