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Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI

This study has been completed.
Sponsor:
Collaborators:
Rehabilitation Institute of Chicago
Shepherd Center, Atlanta GA
Northwestern University
University of Wisconsin, Madison
University of Saskatchewan
Information provided by (Responsible Party):
Randy D. Trumbower, Emory University
ClinicalTrials.gov Identifier:
NCT01272349
First received: January 4, 2011
Last updated: November 20, 2013
Last verified: November 2013

January 4, 2011
November 20, 2013
December 2010
November 2013   (final data collection date for primary outcome measure)
Walking performance [ Time Frame: 1 Week ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01272349 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI

The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypoxia improves breathing in spinally injured rats. These studies have shown that intermittent hypoxia induces spinal plasticity, strengthening neural connections and motor neuron function within the spinal cord. Exposure to mild intermittent hypoxia triggers a cascade of events, including increased production of key proteins and increased sensitivity of spinal cord circuitry necessary for improved breathing.

The ultimate goal of this research is to assess the potential of mild intermittent hypoxia as a therapeutic approach to stimulate recovery of limb function in human patients.

: The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypoxia improves breathing in spinally injured rats. These studies have shown that intermittent hypoxia induces spinal plasticity, strengthening neural connections and motor neuron function within the spinal cord. Exposure to mild intermittent hypoxia triggers a cascade of events, including increased production of key proteins and increased sensitivity of spinal cord circuitry necessary for improved breathing.

The investigators initially hypothesize that daily exposure to intermittent hypoxia for 7 consecutive days will improve limb function in rats and in humans with chronic spinal injuries. First, the investigators will compare limb function in spinally-injured rats which receive mild intermittent hypoxia treatment with rats that did not. The investigators will measure grip strength and locomotor abilities in both groups before treatment and for several months after treatment. The investigators will also examine the spinal cords of these rats to look for the key proteins, which are indicators of spinal plasticity. The investigators will use this information to guide the treatment protocols when the investigators compare limb function in spinal-injured persons with and without intermittent hypoxia treatment.

The second hypothesis is that combining intermittent hypoxia with locomotor training will further improve limb function after spinal injury. To test this idea, the investigators will compare limb function in spinally-injured rats which have received combined intermittent hypoxia and treadmill training with rats which only received intermittent hypoxia or locomotor training alone. The investigators will examine key proteins in the spinal cords of these rats to determine whether the combination of hypoxia and training further alters these indicators of plasticity. The investigators will also compare limb function in spinally-injured humans who receive both intermittent hypoxia and locomotor treadmill training with those who receive either treatment alone.

The ultimate goal of this research is to assess the potential of mild intermittent hypoxia as a therapeutic approach to stimulate recovery of limb function in human patients.

Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Spinal Cord Injury
  • Other: Acute intermittent hypoxia
    30 minutes of intermittent breathing low oxygen followed by walking on a body-weight support treadmill
    Other Name: breathing low oxygen
  • Other: Room air
    30 minutes of breathing room air followed by walking on a body-weight support treadmill
    Other Name: breathing room air
  • Experimental: Low oxygen
    Intervention: Other: Acute intermittent hypoxia
  • Sham Comparator: Room Air
    Intervention: Other: Room air
Hayes HB, Jayaraman A, Herrmann M, Mitchell GS, Rymer WZ, Trumbower RD. Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial. Neurology. 2014 Jan 14;82(2):104-13. doi: 10.1212/01.WNL.0000437416.34298.43. Epub 2013 Nov 27.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
19
November 2013
November 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • medical clearance to participate
  • lesion below C5 and above T12 with non-progressive etiology
  • classified as motor-incomplete
  • injury greater than 12 months
  • ambulatory with minimal assistance

Exclusion Criteria:

  • Concurrent severe medical illness (i.e., infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed decubiti, and history of cardiac or pulmonary complications)
  • Pregnant women because of the unknown affects of AIH on pregnant women and fetus
  • History of seizures, brain injury, and/or epilepsy
  • Diagnosed with obstructive sleep apnea
  • Undergoing concurrent physical therapy
  • Any contraindications to EMG testing procedures (skin sensitivity)
  • Any contraindications to passive movement of the limbs (e.g., joint immobility, hemodynamic instability)
  • Score of < 24 on Mini-Mental Exam
Both
18 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01272349
IRB00035986a, W81XWH-10-1-0832
Yes
Randy D. Trumbower, Emory University
Emory University
  • Rehabilitation Institute of Chicago
  • Shepherd Center, Atlanta GA
  • Northwestern University
  • University of Wisconsin, Madison
  • University of Saskatchewan
Principal Investigator: Randy D Trumbower, PT, PhD Emory University
Emory University
November 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP