Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

The recruitment status of this study is unknown because the information has not been verified recently.

Verified November 2010 by Sheffield Teaching Hospitals NHS Foundation Trust.
Recruitment status was Recruiting

Sponsor:

Collaborator:

University of Sheffield

Information provided by:

Sheffield Teaching Hospitals NHS Foundation Trust

ClinicalTrials.gov Identifier:

NCT01235494

First received: November 4, 2010

Last updated: NA

Last verified: November 2010

History: No changes posted

Tracking Information
First Received Date ^ICMJE	November 4, 2010
Last Updated Date	November 4, 2010
Start Date ^ICMJE	July 2010
Primary Completion Date	Not Provided
Current Primary Outcome Measures ^ICMJE	Not Provided
Original Primary Outcome Measures ^ICMJE	Not Provided
Change History	No Changes Posted
Current Secondary Outcome Measures ^ICMJE	Not Provided
Original Secondary Outcome Measures ^ICMJE	Not Provided
Current Other Outcome Measures ^ICMJE	Not Provided
Original Other Outcome Measures ^ICMJE	Not Provided

Descriptive Information
Brief Title ^ICMJE	Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Official Title ^ICMJE	Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Brief Summary	To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas
Detailed Description	Not Provided
Study Type ^ICMJE	Interventional
Study Phase	Phase 1
Study Design ^ICMJE	Intervention Model: Single Group Assignment Masking: Open Label
Condition ^ICMJE	Healthy Volunteers
Intervention ^ICMJE	Other: polarised 3 helium 1 inhalation (= 1 litre)
Study Arm (s)	Experimental: polarised 3 helium inhaled gas Intervention: Other: polarised 3 helium
Publications *	Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Recruiting
Estimated Enrollment ^ICMJE	20
Completion Date	Not Provided
Primary Completion Date	Not Provided
Eligibility Criteria ^ICMJE	Inclusion Criteria: age 18 -70 Exclusion Criteria: contraindication to MRI Resting oxygen saturation <95% Volunteers requiring bronchodilators less than 4 hourly additional respiratory diagnoses pregnancy
Gender	Both
Ages	18 Years to 70 Years
Accepts Healthy Volunteers	Yes
Contacts ^ICMJE	Not Provided
Location Countries ^ICMJE	United Kingdom

Administrative Information
NCT Number ^ICMJE	NCT01235494
Other Study ID Numbers ^ICMJE	STH15080
Has Data Monitoring Committee	No
Responsible Party	Prof Paul Griffiths, Univeristy of Sheffield
Study Sponsor ^ICMJE	Sheffield Teaching Hospitals NHS Foundation Trust
Collaborators ^ICMJE	University of Sheffield
Investigators ^ICMJE	Not Provided
Information Provided By	Sheffield Teaching Hospitals NHS Foundation Trust
Verification Date	November 2010
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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