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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2013 by Sheffield Teaching Hospitals NHS Foundation Trust
Sponsor:
Collaborator:
University of Sheffield
Information provided by:
Sheffield Teaching Hospitals NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT01235494
First received: November 4, 2010
Last updated: December 3, 2013
Last verified: December 2013

November 4, 2010
December 3, 2013
July 2010
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Complete list of historical versions of study NCT01235494 on ClinicalTrials.gov Archive Site
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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Not Provided
Interventional
Phase 1
Intervention Model: Single Group Assignment
Masking: Open Label
Healthy Volunteers
Other: polarised 3 helium
1 inhalation (= 1 litre)
Experimental: polarised 3 helium
inhaled gas
Intervention: Other: polarised 3 helium
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
20
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Inclusion Criteria:

  • age 18 -70

Exclusion Criteria:

  • contraindication to MRI
  • Resting oxygen saturation <95%
  • Volunteers requiring bronchodilators less than 4 hourly
  • additional respiratory diagnoses
  • pregnancy
Both
18 Years to 70 Years
Yes
United Kingdom
 
NCT01235494
STH15080
No
Prof Paul Griffiths, Univeristy of Sheffield
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield
Not Provided
Sheffield Teaching Hospitals NHS Foundation Trust
December 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP