Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2010 by Hadassah Medical Organization.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT01221896
First received: October 14, 2010
Last updated: NA
Last verified: October 2010
History: No changes posted

October 14, 2010
October 14, 2010
January 2011
January 2014   (final data collection date for primary outcome measure)
Improved localization of a parathyroid adenoma
Same as current
No Changes Posted
Facilitation of detection of the parathyroid adenoma at surgery
Same as current
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Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma
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The purpose of the study is to determine a possible input of C11-Choline PET/CT in identification and localization of a parathyroid adenoma (PTA).

Preoperative localization of a PTA has been previously documented in multiple series, and is usually based on scintigraphy and on US.

Currently, the conventional technique for localization of a PTA is a dual-isotope scan with Tc99m-MIBI and Tc99m pertechnetate. This study is acquired over at least 3 hours, includes two i.v. injections and the patient has to stay 15-30 min per acquisition under the camera.

In addition, there is no anatomical imaging and further correlation with US is usually recommended.

In contrast, PET/CT study with C11-Choline takes as long as 10 min., includes one injection, and provides data of higher resolution of functional (PET) and anatomical imaging (CT).

Furthermore, dosimetric data shows that the total effective dose from Tc99mMIBI and Tc99m pertechnetate injection is (without CT): 0.5957 rem; and from C11-Choline injection and CT of a chest is: 0.3128 - 0.8628rem.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Patients with elevated PTH in search of a PTA

Hyperparathyroidism
Procedure: C11-Choline PET/CT
Hyperparathyroidism
Patients with hyperparathyroidism, prior to surgery.
Intervention: Procedure: C11-Choline PET/CT
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
100
Not Provided
January 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Elevation of a calcium and parathyroid hormone in the serum
Both
18 Years to 80 Years
No
Contact: Marina Orevi, MD 0508946211 marinaor@hadassah.org.il
Israel
 
NCT01221896
choline2010-HMO-CTIL
Not Provided
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Hadassah Medical Organization
Not Provided
Not Provided
Hadassah Medical Organization
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP