4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by Hallym University Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by (Responsible Party):
Hallym University Medical Center
ClinicalTrials.gov Identifier:
NCT01211899
First received: September 29, 2010
Last updated: October 4, 2011
Last verified: September 2010

September 29, 2010
October 4, 2011
September 2010
September 2012   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01211899 on ClinicalTrials.gov Archive Site
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4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock
Incidence and Prognosis of Disseminated Intravscular Coagulation in Patients Severe Sepsis and Septic Shock; Association With 4G/5G Polymorphism of PAI-1 Gene

Data on 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene are limited in Asian patients with sepsis. Therefore, the investigators aim to prospectively investigate the incidence of 4G/5G polymorphism and its relationship with disseminated intravascluar coagulatin in patients with severe sepsis and septic shock.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Blood sample for 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1)

Probability Sample

Patients admitted to the ICU for severe sepsis or septic shock

Severe Sepsis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
160
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September 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adult patinents aged > 18 years, Patients satisfying the criteria by 2008 Surviving Sepsis Campagin, Patients who are determined as having a sepsis within 24 hours of ICU stay

Exclusion Criteria:

  • Do-not-resuscitate, cardiopulmonary resuscitation, ICU stay < 1 day, Refusal to participate in the study, Hematologic malignancy or liver cirrhosis (Child C), Congenital abnormality in coagulation system, Transfer from other ICUs or hospitals
Both
18 Years and older
No
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NCT01211899
f2000tj2
Yes
Hallym University Medical Center
Hallym University Medical Center
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Hallym University Medical Center
September 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP