MiRNAs Evaluate the Prognosis of Sepsis (METPS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by Chinese PLA General Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Chinese PLA General Hospital
ClinicalTrials.gov Identifier:
NCT01207531
First received: September 17, 2010
Last updated: September 22, 2010
Last verified: September 2010

September 17, 2010
September 22, 2010
July 2010
November 2010   (final data collection date for primary outcome measure)
all cause mortality [ Time Frame: 28days after admited in ICU ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01207531 on ClinicalTrials.gov Archive Site
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MiRNAs Evaluate the Prognosis of Sepsis
miRNA in the Evaluation of the Value of Sepsis Prognosis Prospective Observational Study

Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.

The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

human serum

Non-Probability Sample

within 24 hours after admited in ICU

Sepsis
Not Provided
  • Survival Group
  • Death group
Wang H, Zhang P, Chen W, Feng D, Jia Y, Xie L. Serum microRNA signatures identified by Solexa sequencing predict sepsis patients' mortality: a prospective observational study. PLoS One. 2012;7(6):e38885. doi: 10.1371/journal.pone.0038885. Epub 2012 Jun 15.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
April 2011
November 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of sepsis
  • Patients who agree with the study

Exclusion Criteria:

  • Aged <18 years;
  • Into the group who died within 24 hours;
  • Agranulocytosis (<0.5 × 109 / L);
  • Combined HIV infection.
Both
18 Years and older
Yes
Contact: Huijuan Wang, master +86 13466791738 wanghuijuan301@gmail.com
China
 
NCT01207531
301PLAGH-2010915
Yes
Lixin Xie, Pneumology Department of Chinese PLA General Hospital
Chinese PLA General Hospital
Not Provided
Study Director: Lixin Xie, Doctor Pneumology Department of chinese PLA General Hospital
Chinese PLA General Hospital
September 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP