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Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
Collaborators:
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Groupe Fontalvie
ClinicalTrials.gov Identifier:
NCT01183052
First received: August 16, 2010
Last updated: September 3, 2012
Last verified: September 2012

August 16, 2010
September 3, 2012
June 2009
December 2010   (final data collection date for primary outcome measure)
Cellular effects of exercise training at the ventilatory threshold intensity [ Time Frame: 6 to 8 weeks ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT01183052 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients
Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Interventional
Not Provided
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
COPD Patients
Other: Training
20 sessions of training
Other Name: CT
Training
20 sessions of training
Intervention: Other: Training
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
December 2010
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Sedentary mild to severe COPD patients

Exclusion Criteria:

  • Neuromuscular disease
  • Chronic heart failure
  • Renal diseases
  • Liver diseases
  • Obesity
Both
50 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT01183052
2009-A00426-51
Yes
Groupe Fontalvie
Groupe Fontalvie
  • Centre Hospitalier Régional Universitaire Montpellier
  • Institut National de la Santé Et de la Recherche Médicale, France
Principal Investigator: Maurice MH Hayot, MCU-PH Institut National de la Santé Et de la Recherche Médicale, France
Groupe Fontalvie
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP