Regulation of Endothelial Progenitor Cells by Short-Term Exercise (EPC-Ex)

This study is currently recruiting participants.
Verified July 2013 by Baltimore VA Medical Center
Sponsor:
Collaborators:
Baltimore VA Medical Center
University of Maryland
Information provided by (Responsible Party):
Steven J. Prior, Ph.D., Baltimore VA Medical Center
ClinicalTrials.gov Identifier:
NCT01169831
First received: July 23, 2010
Last updated: July 2, 2013
Last verified: July 2013

July 23, 2010
July 2, 2013
July 2011
November 2013   (final data collection date for primary outcome measure)
  • Baseline Endothelial progenitor cell number [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
  • Final Endothelial Progenitor Cell Number [ Time Frame: Day 15 ] [ Designated as safety issue: No ]
Endothelial progenitor cell number [ Time Frame: Baseline, Post-Exercise ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01169831 on ClinicalTrials.gov Archive Site
  • Baseline Endothelial Reactivity [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
  • Final Endothelial Reactivity [ Time Frame: Day 15 ] [ Designated as safety issue: No ]
Endothelial Reactivity [ Time Frame: Baseline, Post-exercise ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
  • Aging
  • Exercise
  • Cardiovascular Disease
  • Other: Exercise Training
    2 weeks of daily aerobic exercise training
  • Other: Exercise Cessation
    Stopping all exercise for 2 weeks
  • Experimental: Sedentary Older Adults
    Intervention: Other: Exercise Training
  • Experimental: Older Endurance Athletes
    Intervention: Other: Exercise Cessation
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
60
November 2013
November 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria:

  • history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension
Both
50 Years to 80 Years
Yes
Contact: Sarah Horlitz, M.S. 410-605-7000 ext 4823 sarah.horlitz@va.gov
United States
 
NCT01169831
HP-00045413
Yes
Steven J. Prior, Ph.D., Baltimore VA Medical Center
University of Maryland, Baltimore County
  • Baltimore VA Medical Center
  • University of Maryland
Principal Investigator: Steven J Prior, Ph.D. University of Maryland, Baltimore County
Baltimore VA Medical Center
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP