Creatine Supplementation and Cognition

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01164020
First received: July 15, 2010
Last updated: January 17, 2013
Last verified: January 2013

July 15, 2010
January 17, 2013
August 2010
December 2012   (final data collection date for primary outcome measure)
cognitive function [ Time Frame: six months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01164020 on ClinicalTrials.gov Archive Site
physical capacity [ Time Frame: six months ] [ Designated as safety issue: No ]
muscle strength and function
Same as current
Not Provided
Not Provided
 
Creatine Supplementation and Cognition
Not Provided

Resistance training as well as creatine supplementation may be beneficial for cognitive function, such as memory and attention. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on cognitive function in elderly women.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
  • Cognition
  • Aging
  • Dietary Supplement: creatine supplementation
    20g/d for 7 days followed by 5g/d for 23 weeks
  • Other: Placebo (Dextrose)
    20g/d for 7 days followed by 5g/d for 23 weeks
  • Other: Resistance training
    resistance training twice a week for 24 weeks
  • Placebo Comparator: placebo control
    this only receives placebo (dextrose)
    Intervention: Other: Placebo (Dextrose)
  • Experimental: placebo and exercise
    this is trained and receives placebo
    Interventions:
    • Other: Placebo (Dextrose)
    • Other: Resistance training
  • Experimental: creatine supplementation
    this is non-exercise trained and receives creatine supplementation
    Intervention: Dietary Supplement: creatine supplementation
  • Experimental: Creatine and Exercise
    this is exercised trained and receives creatine supplementation
    Interventions:
    • Dietary Supplement: creatine supplementation
    • Other: Resistance training
Alves CR, Merege Filho CA, Benatti FB, Brucki S, Pereira RM, de Sá Pinto AL, Lima FR, Roschel H, Gualano B. Creatine supplementation associated or not with strength training upon emotional and cognitive measures in older women: a randomized double-blind study. PLoS One. 2013 Oct 3;8(10):e76301. doi: 10.1371/journal.pone.0076301.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
56
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • women older than 60 years old

Exclusion Criteria:

  • cardiovascular diseases or muscular disturbances precluding exercise training
  • drugs affecting the cognition
Female
60 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT01164020
Creatine and Cognition
No
Bruno Gualano, University of Sao Paulo
University of Sao Paulo
Not Provided
Principal Investigator: Bruno Gualano, PhD University of Sao Paulo
Principal Investigator: Antonio H Lancha Junior, PhD University of Sao Paulo
University of Sao Paulo
January 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP