Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance

Adenosine-triphosphate (ATP) serves as the sole energy source for muscle contraction. Therefore human performance of brief maximal exercise is limited, in part, by the availability of ATP to the contracting muscle. Because muscle ATP storage is small (enough to sustain maximal exercise for less than 1 second), factors that enhance either storage or resynthesis of ATP may have a positive impact on repeated muscle contractions. The current study will test the hypothesis that increasing ATP availability to muscle via oral supplementation will improve performance of repeated high intensity exercise as measured by a) work performed in each of the three 50 contraction fatigue tests, b) sum of total work performed, and c) percentage decrement in total work from the first to third third 50 contraction test.

To date we have studied 10 subjects who have followed through with all 3 of the original interventions (Placebo, 250 mg PeakATP/d and 400 mg PeakATP/d). Currently we have received approval and are expanding the study with 5 additional subjects who will receive the Placebo, 400 mg PeakATP/d and the 400 mg PealATP/d plus proprietary blend interventions.

• Dietary Supplement: PeakATP 250
  The nutritional intervention provides for oral ingestion of 250 mg PeakATP per day
• Dietary Supplement: Placebo
  Placebo capsules that are comparable in size and color to the active comparator for blinding purposes
• Dietary Supplement: PeakATP 400
  The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day
• Dietary Supplement: PeakATP 400 plus proprietary blend
  The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day plus a proprietary blend of additional nutrients

• Placebo Comparator: Placebo
  Oral placebo capsules similar in color and size to the intervention
  Intervention: Dietary Supplement: Placebo
• Active Comparator: PeakATP 250
  Oral supplement capsules containing 250 mg/day of PeakATP
  Intervention: Dietary Supplement: PeakATP 250
• Active Comparator: PeakATP 400
  Oral supplement capsules containing 400 mg/day of PeakATP
  Intervention: Dietary Supplement: PeakATP 400
• Active Comparator: PeakATP 400 plus proprietary blend
  Oral supplement capsules containing 400 mg/day of PeakATP plus a proprietary blend
  Intervention: Dietary Supplement: PeakATP 400 plus proprietary blend

Inclusion Criteria:

• No major medical conditions;
• Able to perform fatigue testing procedures;
• Not currently taking prescription medications;
• Not currently taking dietary supplements (a daily multi-vitamin not exceeding RDA is permitted)

Exclusion Criteria:

• Major medical condition affecting metabolism or general function;
• Not able to perform fatigue testing;
• Taking prescription medications;
• Taking a dietary supplement other than a multi-vitamin not exceeding RDA