Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Yonsei University
ClinicalTrials.gov Identifier:
NCT01132157
First received: May 24, 2010
Last updated: March 4, 2014
Last verified: March 2014

May 24, 2010
March 4, 2014
March 2010
January 2012   (final data collection date for primary outcome measure)
  • BUN(Blood Urea Nitrogen) [ Time Frame: 1 hour after surgery ] [ Designated as safety issue: No ]
    The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
  • Cr density [ Time Frame: 1 hour after surgery ] [ Designated as safety issue: No ]
    The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
  • estimated GFR(Glomerular Filtration Ratio) [ Time Frame: 1 hour after surgery ] [ Designated as safety issue: No ]
    The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
  • urine output to check the the degree of protection for renal function [ Time Frame: 1 hour after surgery ] [ Designated as safety issue: No ]
    The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
BUN(Blood Urea Nitrogen), Cr density, estimated GFR and urine output to check the the degree of protection for renal function [ Time Frame: 1 hour after surgery ] [ Designated as safety issue: No ]
The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
Complete list of historical versions of study NCT01132157 on ClinicalTrials.gov Archive Site
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Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation
The Comparison of Preconditioning Effect of Desflurane and Antiapoptotic Effect of Propofol in Patients With Kidney Transplantation

Ischemia/reperfusion (IR) injury is the major cause of early renal dysfunction and acute renal failure of the transplanted kidney after renal transplantation. In 1986, Murry et al. described the phenomenon "ischemic preconditioning". Also, it was reported that a few non-ischemic stimuli could provide cellular tolerance against major ischemia through a mechanism similar to ischemic preconditioning. In an animal study, 1 minimal alveolar concentration of volatile anesthetics - a clinically relevant concentration - was reported to have a protective effect against ischemia/reperfusion injury, the effect being variable between types of anesthetics. Also, there were somm reports that intravenous anesthetics such as propofol could reduce IR injury by decreasing oxidative stress and apoptosis.

By reducing the ischemia/reperfusion injury of the grafted kidney, the morbidity and mortality related to renal transplantation can be reduced as well. The objective of this study is to find out whether, according to the type of anesthetics (Desflurane vs. Propofol), there is a difference in the protective effect against ischemia/reperfusion injury of the grafted kidney in patients receiving renal transplantation.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Supportive Care
  • Healthy
  • End Stage Renal Disease
  • Drug: Desflurane
    In Desflurane group, donors and their recipients will be anesthetized with desflurane and remifentanil. In contrast, in Propofol group, donors will be anesthetized with Propofol and remifentanil and recipients will be anesthetized with desflurane and remifentanil.
  • Drug: Propofol
    In Desflurane group, donors and their recipients will be anesthetized with desflurane and remifentanil. In contrast, in Propofol group, donors will be anesthetized with Propofol and remifentanil and recipients will be anesthetized with desflurane and remifentanil.
  • Experimental: Propofol group
    Intervention: Drug: Propofol
  • Active Comparator: Desflurane group
    Intervention: Drug: Desflurane
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
99
January 2012
January 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy kidney donors and their recipients of renal transplantation.

Exclusion Criteria:

  • a donor that has any medical or surgical history,
  • a recipient that is scheduled to have any other surgery with renal transplantation surgery.
Both
20 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01132157
4-2009-0598
No
Yonsei University
Yonsei University
Not Provided
Principal Investigator: Bon Nyeo Koo, MD, Ph.D Severance hospital, Yonsei University College of Medicine
Yonsei University
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP