Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2010 by Chang Gung Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier:
NCT01131442
First received: May 25, 2010
Last updated: May 26, 2010
Last verified: May 2010

May 25, 2010
May 26, 2010
November 2008
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Complete list of historical versions of study NCT01131442 on ClinicalTrials.gov Archive Site
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Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)
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Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.

Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder.Many children suffered from this disease and had impact on their daily life. However, the underlying pathophysiologic mechanisms remain to be elucidate. Dysregulation of the gut immune system is considered an important pathophysiology. We want to investigate the immunological changes in the IBS children.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample

out patient clinics in the hospital

  • Irritable Bowel Syndrome
  • Children
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  • The patient group
  • healthy control group
Hua MC, Lai MW, Kuo ML, Yao TC, Huang JL, Chen SM. Decreased interleukin-10 secretion by peripheral blood mononuclear cells in children with irritable bowel syndrome. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):376-81. doi: 10.1097/MPG.0b013e3181fd9816.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
40
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Inclusion Criteria:

  • (5-18y/o) with IBS,
  • All patients had chronic or relapsing symptoms of IBS consistent with the ROME II criteria

Exclusion Criteria:

  • A history of psychologic disorders, probiotics, anti-inflammatory, analgesic, or immunosuppressive medication (nonsteroidal anti-inflammatory drugs, steroids) within the past 3 months were excluded
Both
5 Years to 18 Years
Yes
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Taiwan
 
NCT01131442
CMRPG270371
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Chang Gung Memorial Hospital
Chang Gung Memorial Hospital
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Chang Gung Memorial Hospital
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP