Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Jesper Hallas, University of Southern Denmark
ClinicalTrials.gov Identifier:
NCT01128660
First received: May 21, 2010
Last updated: February 1, 2013
Last verified: February 2013

May 21, 2010
February 1, 2013
June 2010
June 2010   (final data collection date for primary outcome measure)
FC(Pharm) [ Time Frame: cross-sectional study with data aquisition over one year ] [ Designated as safety issue: No ]
The pharmacy fidelity coefficient, FC(Pharm), is a measure of what proportion of individual patients' medication that are accounted for by the most used pharmacy.
  • FC(Pharm) [ Designated as safety issue: No ]
    The pharmacy fidelity coefficient, FC(Pharm), is a measure of what proportion of individual patients' medication that are accounted for by the most used pharmacy.
  • FC(Presc) [ Designated as safety issue: No ]
    The prescriber fidelity coefficient, FC(Presc), is a measure of what proportion of individual patients' medication that are accounted for by the most used prescriber.
Complete list of historical versions of study NCT01128660 on ClinicalTrials.gov Archive Site
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Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.
Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.

The purpose of this study is to twofold. The investigators wish to introduce a new patient-descriptive parameter, the 'Fidelity Coefficient', and use it to assess and compare the overview of patient's medication possessed by the general practitioners and the pharmacies.

The fidelity coefficient, FC, is a measure of what proportion of individual patients' medication that are accounted for by the most used prescriber and the most used pharmacy. Each patient therefore has two values, one describing his fidelity towards his most used prescriber, FCPresc, and one describing his fidelity towards his most used pharmacy, FCPharm.

The investigators intend to assess this parameter in an observational population scale database study, using standard descriptive statistics, and subsequently compare the obtained average FCPresc and FCPharm.

Furthermore, the investigators will analyze the two obtained FCs for dependency of a predefined list of variables: age, gender, number of prescriptions, whether the most frequent prescriber was a GP and whether the most used pharmacy was urban.

Finally, the investigators intend to analyze which medications (grouped using the ATC-system with 4 digits, e.g. C07A) that has the highest proportion of prescriptions that were either issued by a non-main prescriber or redeemed at a non-main pharmacy, which roughly translates into the most 'infidel' medications. To insure relevance we intend to use a cut-off-value of the medication being prescribed at least 50.000 times, which equals about 85 % of the data according to preceding analyses.

The data for this study will be obtained from the Odense University Pharmacoepidemiological Database (OPED). In brief, it is a research database with full coverage of all reimbursed prescriptions in the Region of Southern Denmark (1.2 million inhabitants). The data included in each prescription record includes the prescription holder, the prescriber, the pharmacy, the date of dispensing and a full account of the dispensed product, including substance, brand name, route of administration, ATC-code and Defined Daily Dose (DDD).

Some drugs are exempt from re-imbursement and thus not covered by the database, including benzodiazepines, oral contraceptives, laxatives and certain antibiotics.

Observational
Observational Model: Cohort
Time Perspective: Retrospective
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Probability Sample

Residents of Region of Southern Denmark during 2009.

Misuse of Prescription Only Drugs
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RSD-citizens
Residents of Southern Denmark, who filed more than 9 prescriptions during 2009.
Pottegård A, Hallas J. Physicians' and pharmacies' overview of patients' medication. An analysis of fidelity coefficients. Eur J Clin Pharmacol. 2011 Sep;67(9):919-24. doi: 10.1007/s00228-011-1026-3. Epub 2011 Mar 12. Erratum in: Eur J Clin Pharmacol. 2012 Jan;68(1):107.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
283388
August 2010
June 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Having filed more than 9 prescriptions during 2009.

Exclusion Criteria:

  • None
Both
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No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT01128660
JH-AP-001
No
Jesper Hallas, University of Southern Denmark
University of Southern Denmark
Not Provided
Principal Investigator: Jesper Hallas, MD, PhD Professor, Research Unit of Clinical Pharmacology, University of Southern Denmark.
Principal Investigator: Anton Pottegard, BSc in Pharm Guest Researcher, Research Unit of Clinical Pharmacology, University of Southern Denmark.
University of Southern Denmark
February 2013

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