Role of CCL2 in Alcoholic Liver Diseases

This study has been completed.
Sponsor:
Information provided by:
Erasme University Hospital
ClinicalTrials.gov Identifier:
NCT01128010
First received: May 20, 2010
Last updated: NA
Last verified: December 2002
History: No changes posted

May 20, 2010
May 20, 2010
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No Changes Posted
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Role of CCL2 in Alcoholic Liver Diseases
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Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample

Consecutive patients undergoing transjugular liver biopsy for alcoholic liver disease will be include in the study to measure plasma levels and hepatic expression of CCL2. We determine also the rs1024611 polymorphism of these patients. All these parameters are correlated to severity of the disease.

The frequency of the presence of this polymorphism was also compared to a population of healthy subjects.

Alcoholic Liver Disease
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  • alcoholic liver disease
    alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution
  • controls
    Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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ALD patients

Inclusion Criteria:

  • Excess alcohol intake
  • Abnormality of liver biopsy compatible with alcoholic aetiology
  • Caucasian ethnicity

Exclusion Criteria:

  • Presence of any other chronic liver disease
  • co-infection with HIV Controls Inclusion criteria
  • Caucasian ethnicity
  • presence of a disease
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
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NCT01128010
DD-CCL2
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Erasme University Hospital
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Erasme University Hospital
December 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP