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Use of Echocardiography in the Evaluation of Chest Pain in the Emergency Department

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2010 by New York University School of Medicine.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
New York University School of Medicine
ClinicalTrials.gov Identifier:
NCT01125072
First received: May 14, 2010
Last updated: May 17, 2010
Last verified: May 2010

May 14, 2010
May 17, 2010
June 2005
December 2009   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01125072 on ClinicalTrials.gov Archive Site
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Use of Echocardiography in the Evaluation of Chest Pain in the Emergency Department
Use of Echocardiography in the Evaluation of Chest Pain in the Emergency Department

Chest pain is one of the most common complaints that brings a patient to the emergency department (ED). The differential diagnosis of chest pain is broad and includes cardiac as well as non-cardiac diseases. One of the initial goals in the ED evaluation of a patient presenting with chest pain is to rapidly and accurately diagnose the presence or absence of acute coronary syndrome. The diagnostic accuracy of the initial routine evaluation is often limited and results in frequent admissions for patients presenting with chest pain for further diagnostic testing.

Echocardiography has a high sensitivity and specificity for the diagnosis of acute myocardial infarction. Tissue Doppler imaging with strain and strain rate (SR) measurement is a new echocardiographic technique, which enables accurate assessment of regional left ventricular systolic and diastolic function. Prior studies have shown that abnormal strain and SR are highly sensitive markers of ischemia. Acute ischemia induces early systolic thinning and a delay in the onset of systolic thickening, a progressive decrease in the rate and degree of maximal systolic thickening, and an abnormal ischemia-related thickening which occurs after aortic valve closure. A major obstacle to the routine use of echocardiography in the ED is the need for portable studies, using heavy, bulky portable echo machines. There are currently available portable hand-held echo machines (GE-Vivid I) that produce high quality images and offer an opportunity to incorporate echocardiography into routine practice in the ED.

We propose to study the use of early, portable echocardiography, with detailed assessment of wall motion and left ventricular function by strain and strain rate measurements, for the evaluation of chest pain in the ED. We hypothesize that an early with detailed left ventricular function assessment will be highly sensitive and specific for the diagnosis of myocardial ischemia, and will enable rapid triage of patients who present to the ED with chest pain.

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Observational
Observational Model: Cohort
Time Perspective: Retrospective
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Non-Probability Sample

All patients presenting to the emergency department with chest pain and are admitted to rule out acute coronary syndrome

Chest Pain
Other: Echocardiography with strain analysis
Clinical routine echocardiogram with additional off line strain analysis
entire cohort
patients presenting to the emergency department with chest pain and being admitted to rule out acute coronary syndrome
Intervention: Other: Echocardiography with strain analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
118
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December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Age 18 or older
  2. Chief complaint on presentation to ED: chest pain
  3. Differential diagnosis includes acute coronary syndrome as determined by the Emergency physician or admitting attending.
  4. Admission to the hospital required for further cardiac work up.

Exclusion Criteria:

  1. Obvious noncardiac cause of the chest pain
  2. Patient requires urgent intervention before echo can be obtained
  3. Failure to obtain informed consent
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01125072
05-264
No
Itzhak Kronzon, MD, NYU School of Medicine
New York University School of Medicine
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New York University School of Medicine
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP