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The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

This study has been completed.
Sponsor:
Collaborator:
University of Malaya
Information provided by:
Malaysia Palm Oil Board
ClinicalTrials.gov Identifier:
NCT01124487
First received: May 12, 2010
Last updated: May 14, 2010
Last verified: May 2010
History of Changes

May 12, 2010
May 14, 2010
August 2009
September 2009   (final data collection date for primary outcome measure)
Triacylglycerol (TAG) [ Time Frame: 4 h ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01124487 on ClinicalTrials.gov Archive Site
Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers [ Time Frame: 4 h ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers
The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.

Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.

Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
Lipid Profile
Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
  • Experimental: palm olein
    Intervention: Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
  • Experimental: olive oil
    Intervention: Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
  • Experimental: lard
    Intervention: Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
September 2009
September 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age: 18-45 years
  • BMI : 18.5-30 kg/m^2
  • Healthy, men

Exclusion Criteria:

  • medical history of cardiovascular disease, cancer, diabetes or chronic diseases
  • BMI < 18.5 OR > 30 kg/m^2
  • waist hip ratio > 0.9
  • total cholesterol > 5.2 mmol/L
  • triacylglycerol (TAG) > 2.2 mmol/L
  • current use of antihypertensive or lipid lowering medication
Male
18 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Malaysia
 
NCT01124487
A001/09
Yes
Dr. Kalanithi Nesaretnam, Malaysia Palm Oil Board
Malaysia Palm Oil Board
University of Malaya
Principal Investigator: Teng Kim Tiu, Msc Malaysia Palm Oil Board and University of Malaya
Malaysia Palm Oil Board
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP