Study of the Metabolism of Two Magnesium Supplements in Healthy Volunteers

This study is not yet open for participant recruitment.
Verified June 2012 by University of Aarhus
Sponsor:
Collaborators:
Gunnar Kjems APS
GCP-unit at Aarhus University Hospital, Aarhus, Denmark
Aarhus University Hospital
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT01113138
First received: April 27, 2010
Last updated: June 18, 2012
Last verified: June 2012

April 27, 2010
June 18, 2012
December 2012
December 2012   (final data collection date for primary outcome measure)
Pharmacokinetic parameters [ Time Frame: Two years ] [ Designated as safety issue: No ]
Clearance, half-life & absorption fraction
Same as current
Complete list of historical versions of study NCT01113138 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Study of the Metabolism of Two Magnesium Supplements in Healthy Volunteers
Pharmacokinetic Study of Mablet as Oral Supplement and Magnesium Sulfate as Infusion

The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that daily magnesium supplement will benefit patients with asthma and chronic obstructive pulmonary disease.

The aim of this part of the project is to study the pharmacokinetics of the following two magnesium supplements:

  • Mablet (dietary supplement)
  • Magnesium Sulfate (solution for infusion)
Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
  • Asthma
  • Chronic Obstructive Pulmonary Disease
  • Dietary Supplement: Mablet (Magnesium-supplement)
    Mablet: Magnesium hydroxide/ -oxide (360 mg/tablet) 3 tablets as a single dose Produced by: Gunnar Kjems APS
    Other Name: Mablet
  • Drug: Magnesium Sulfate
    Solution for a single bolus-infusion, containing 2 grams of magnesium sulfate.
    Other Name: Magnesiumsulfat 'SAD'
  • No Intervention: Baseline
  • Active Comparator: Mablet
    Intervention: Dietary Supplement: Mablet (Magnesium-supplement)
  • Active Comparator: Magnesium sulfate
    Intervention: Drug: Magnesium Sulfate

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
10
March 2013
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy volunteers.

Exclusion Criteria:

  • Smokers,
  • Using pharmaceuticals/supplements,
  • Vegans/vegetarians,
  • Major changes in eating habits within one week prior to study start.
Male
18 Years and older
Yes
Contact: Ronald Dahl, Professor +4589492106 ronadahl@rm.dk
Contact: Mette KB Dolberg, Cand. med. +4589492106 mettdolb@rm.dk
Denmark
 
NCT01113138
9727b
Yes
University of Aarhus
University of Aarhus
  • Gunnar Kjems APS
  • GCP-unit at Aarhus University Hospital, Aarhus, Denmark
  • Aarhus University Hospital
Principal Investigator: Ronald Dahl, Professor Dept. of Respiratory Medicine, Aarhus University Hospital
University of Aarhus
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP