The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2010 by Tel-Aviv Sourasky Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Herzog Hospital
Information provided by:
Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier:
NCT01108952
First received: April 21, 2010
Last updated: NA
Last verified: April 2010
History: No changes posted

April 21, 2010
April 21, 2010
January 2011
December 2013   (final data collection date for primary outcome measure)
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No Changes Posted
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The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer
The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer

Background: While treatment for pediatric cancer has improved significantly over the past 40 years, the neurotoxic side-effects of the chemotherapy agents themselves are now being recognized. Two drugs suspected of having acute impact on memory performance in children are methotrexate (MTX) and steroids (GCs). In addition, new evidence suggests that this neurotoxicity might actually protect these children from traumatization.

Working hypothesis and aims: This project aims to examine the acute impact of MTX and GC chemotherapy on memory performance in children and young adults with cancer, and the subsequent impact on the development of traumatic symptoms. We hypothesize that MTX and GCs will each produce acute declines in memory performance and that children with greater reductions in memory performance will have fewer traumatic symptoms.

Methods: The investigators will recruit 45 children being treated with MTX or GCs at Dana Children's Hospital. To determine acute impact on memory, a battery of memory tests will be administered before and after a cycle of MTX and before and after a cycle of GCs. In addition, traumatic symptoms will be assessed at each post-chemotherapy evaluation point Expected results: The investigators expect poorer memory performance after MTX and after GCs and that these performance declines will correlate with lower rates of traumatic symptoms.

Importance: The immediate impact of MTX and GCs on memory is not well known, especially in children. In addition, recent findings have led us to hypothesize that chemotherapy-induced deficits in memory function would paradoxically protect these patients from the traumatization often associated with cancer and its treatment. The proposed study will test this novel hypothesis for the first time.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

children with cancer

  • Oncology
  • Trauma
  • Pediatric
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
45
December 2013
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Histologically proven diagnosis of acute lymphoblastic leukemia, non-Hodgkin's lymphoma, or osteosarcoma
  • treatment protocol that includes at least one cycle of methotrexate or exogenous glucocorticoid
  • informed consent to participate in the study, according to institutional guidelines
  • fluency in Hebrew, English, or Arabic
  • age 6 to 25

Exclusion Criteria:

  • Cranial irradiation within the past year
  • serious concomitant systemic disorders (including active infections) that would compromise the safety of the patient or compromise the patient's ability to complete the study
  • active meningitis or seizures occurring less than a month before study enrollment
Both
6 Years to 25 Years
No
Contact: Ronit Elhasid, MD 03 6974270 ronite@tasmc.health.gov.il
Israel
 
NCT01108952
TASMC-09-RE-687-CTIL
No
Ronit Elhasid, MD, Tel-Aviv Sourasky Medical Center
Tel-Aviv Sourasky Medical Center
Herzog Hospital
Principal Investigator: Ronit Elhasid, MD Tel-Aviv Sourasky Medical Center
Tel-Aviv Sourasky Medical Center
April 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP