Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

This study has been completed.

Sponsor:

Collaborators:

The Danish Rheumatism Association

Danish Ministry of Health, Internal Affairs

Danish National Research Council

The Danish Medical Research Council

Information provided by:

Bispebjerg Hospital

ClinicalTrials.gov Identifier:

NCT01090375

First received: March 18, 2010

Last updated: NA

Last verified: March 2010

History: No changes posted

Tracking Information
First Received Date ^ICMJE	March 18, 2010
Last Updated Date	March 18, 2010
Start Date ^ICMJE	August 2008
Primary Completion Date	March 2009 (final data collection date for primary outcome measure)
Current Primary Outcome Measures ^ICMJE	Not Provided
Original Primary Outcome Measures ^ICMJE	Not Provided
Change History	No Changes Posted
Current Secondary Outcome Measures ^ICMJE	Not Provided
Original Secondary Outcome Measures ^ICMJE	Not Provided
Current Other Outcome Measures ^ICMJE	Not Provided
Original Other Outcome Measures ^ICMJE	Not Provided

Descriptive Information
Brief Title ^ICMJE	Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
Official Title ^ICMJE	Not Provided
Brief Summary	In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.
Detailed Description	Not Provided
Study Type ^ICMJE	Interventional
Study Phase	Phase 0
Study Design ^ICMJE	Intervention Model: Parallel Assignment Primary Purpose: Basic Science
Condition ^ICMJE	Osteoarthritis Exercise
Intervention ^ICMJE	Other: Exercise Other: Non Exercise
Study Arm (s)	Experimental: Exercise Intervention: Other: Exercise Placebo Comparator: Non Exercise Intervention: Other: Non Exercise
Publications *	Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE	Not Provided
Completion Date	Not Provided
Primary Completion Date	March 2009 (final data collection date for primary outcome measure)
Eligibility Criteria ^ICMJE	Inclusion Criteria: verified osteoarthritis (x-ray)of the knee, female, Exclusion Criteria: dementia, inflammatory diseases, regular pain medication
Gender	Female
Ages	55 Years to 75 Years
Accepts Healthy Volunteers	Not Provided
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	Not Provided

Administrative Information
NCT Number ^ICMJE	NCT01090375
Other Study ID Numbers ^ICMJE	H-KF-306126
Has Data Monitoring Committee	No
Responsible Party	Not Provided
Study Sponsor ^ICMJE	Bispebjerg Hospital
Collaborators ^ICMJE	The Danish Rheumatism Association Danish Ministry of Health, Internal Affairs Danish National Research Council The Danish Medical Research Council
Investigators ^ICMJE	Not Provided
Information Provided By	Bispebjerg Hospital
Verification Date	March 2010
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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