Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2009 by National Taiwan University Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT01045785
First received: January 8, 2010
Last updated: NA
Last verified: December 2009
History: No changes posted

January 8, 2010
January 8, 2010
December 2009
June 2010   (final data collection date for primary outcome measure)
cardiovascular event, bleeding event,and thrombosis [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
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Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient
Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient

The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.

Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades. Physicians used to check bleeding time as a surrogate marker for uremic bleeding. However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding. Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders. Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin. Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan. Furthermore, we will study aspirin resistance in dialysis patient.

Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

Dialysis patients which follow-up at least monthly at National Taiwan University Hospital

End Stage Renal Disease
Not Provided
  • aspirin responsive
    PFA Col/EPI normal
  • aspirin resistance
    PFA Col/epi showed resistance
Bilgin AU, Karadogan I, Artac M, Kizilors A, Bligin R, Undar L. Hemodialysis shortens long in vitro closure times as measured by the PFA-100. Med Sci Monit. 2007 Mar;13(3):CR141-5.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
300
July 2010
June 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • dialysis >3 months
  • Hb>10 g/dl & Plt > 10000

Exclusion Criteria:

  • using medication which interfere PFA except aspirin
  • terminal disease such as malignancy
  • active vasculitis
Both
20 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01045785
200912018R
No
Jenqwen Huang, Internal Medicine, National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Principal Investigator: Jenqwen Huang, MD National Taiwan University Hospital
National Taiwan University Hospital
December 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP