Text Size

Nicardipine Versus Labetalol During Intubation

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2009 by Seoul National University Bundang Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier:
NCT01041066
First received: December 30, 2009
Last updated: NA
Last verified: September 2009
History: No changes posted

December 30, 2009
December 30, 2009
September 2009
December 2009   (final data collection date for primary outcome measure)
hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate) [ Time Frame: preinduction- 10 min after intubation ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Nicardipine Versus Labetalol During Intubation
Not Provided

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Patients Who Are Intubated for General Anesthesia
  • Endotracheal Intubation
  • Drug: labetalol
    0.4 mg/kg labetalol intravenously 4 min before intubation
  • Drug: nicardipine
    20 ㎍/kg nicardipine intravenously 4 min before intubation
  • Active Comparator: group L
    0.4 mg/kg labetalol
    Intervention: Drug: labetalol
  • Active Comparator: group N
    20 ㎍/kg nicardipine
    Intervention: Drug: nicardipine
Ryu JH, Apfel CC, Whelan R, Jeon YT, Hwang JW, Do SH, Ro YJ, Kim CS. Comparative prophylactic and therapeutic effects of intravenous labetalol 0.4 mg/kg and nicardipine 20 μg/kg on hypertensive responses to endotracheal intubation in patients undergoing elective surgeries with general anesthesia: a prospective, randomized, double-blind study. Clin Ther. 2012 Mar;34(3):593-604. Epub 2012 Feb 24.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
70
Not Provided
December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

  • Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication
Both
20 Years to 65 Years
No
Contact: Jung-Hee Ryu, Ph.D 82-31-787-7497 jinaryu@lycos.co.kr
Korea, Republic of
 
NCT01041066
nicardipine-labetalol
Not Provided
Seoul National University Bundang Hospital
Seoul National University Bundang Hospital
Not Provided
Not Provided
Seoul National University Bundang Hospital
September 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP