Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2009 by Rigshospitalet, Denmark.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Rigshospitalet, Denmark
ClinicalTrials.gov Identifier:
NCT01028599
First received: December 8, 2009
Last updated: NA
Last verified: September 2009
History: No changes posted

December 8, 2009
December 8, 2009
September 2009
December 2009   (final data collection date for primary outcome measure)
Change in maximal oxygen uptake. [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Change inm flow mediated vasodilatation. [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients
Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.

To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
  • Heart Transplantation
  • Exercise Capacity
  • Endothelial Function
Other: Intensive physical exercise
Intensive physical exercise 1 hour three times per week
Experimental: Exercise
Intervention: Other: Intensive physical exercise
Monk-Hansen T, Dall CH, Christensen SB, Snoer M, Gustafsson F, Rasmusen H, Prescott E. Interval training does not modulate diastolic function in heart transplant recipients. Scand Cardiovasc J. 2014 Apr;48(2):91-8. doi: 10.3109/14017431.2013.871058. Epub 2014 Jan 27.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
30
January 2010
December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Heart transplant recipients > 1 year after transplantation

Exclusion Criteria:

  • Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.
Both
Not Provided
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT01028599
H-D-2009-004
No
Dr. Finn Gustafsson, Rigshospitalet
Rigshospitalet, Denmark
Not Provided
Principal Investigator: Finn Gustafsson, MD, PhD Department of Cardiology, Rigshospitalet
Rigshospitalet, Denmark
September 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP