A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study (CRACK-ANT)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2011 by Centre Hospitalier Universitaire de Fort-de-France.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Centre Hospitalier Universitaire de Fort-de-France
ClinicalTrials.gov Identifier:
NCT01025219
First received: December 1, 2009
Last updated: March 21, 2011
Last verified: March 2011

December 1, 2009
March 21, 2011
December 2009
December 2012   (final data collection date for primary outcome measure)
The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva. [ Time Frame: The saliva will be collect at the end of the first visit ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01025219 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study
A Case Control Study on Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction

The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.

Genetic studies show an association between drug addiction and the dopaminergic system and its modulators. Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction. Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction. In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.

Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Dependence, Cocaine
Genetic: Collect 10 ml of Saliva for DNA extraction
After signed written informed consent, all patients and controls have clinical and neuropsychological evaluations (DIGS, WURS, BROWN, BIS, SSS and IGT) for phenotypic diagnosis and collection of saliva for DNA extraction and genotyping diagnosis.
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
600
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria
  • Come from French West Indies (3 grandparents are African-Caribbean)
  • Sign a written informed consent

Exclusion Criteria:

  • Minor
  • Men with no cocaine abuse/dependence according to DSM-IV-TR criteria

For the control:

Inclusion Criteria:

  • Platelets donor
  • No substance abuse/dependence according to DSM-IV-TR criteria
  • Come from French West Indies (3 grandparents are African-Caribbean)
  • Sign a written informed consent

Exclusion Criteria:

  • Minor
  • Men refusing a genetic study
Male
18 Years to 65 Years
Yes
Contact: Jérôme LACOSTE, MD 596 55 20 44 ext +596 jerome.lacoste@chu-fortdefrance.fr
Contact: Jocelyne CRASPAG, Master 596 59 26 98 ext +596 jocelyne.craspag@chu-fortdefrance.fr
France
 
NCT01025219
09/B/01
Yes
RIAM Daniel, CHU de Fort-de-France
Centre Hospitalier Universitaire de Fort-de-France
Not Provided
Principal Investigator: Jérôme LACOSTE, MD CHU de Fort-de-France
Centre Hospitalier Universitaire de Fort-de-France
March 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP