Non-invasive Measurement of Hemoglobin in Retinal Arteries

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2009 by Triemli Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Triemli Hospital
ClinicalTrials.gov Identifier:
NCT01025011
First received: December 2, 2009
Last updated: NA
Last verified: November 2009
History: No changes posted

December 2, 2009
December 2, 2009
March 2008
June 2010   (final data collection date for primary outcome measure)
Correlation of hemoglobin concentration measured in a cubital vein and in a non invasive way using hemoglobinometry in the retinal veins [ Time Frame: 2.5 years ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
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Non-invasive Measurement of Hemoglobin in Retinal Arteries
Non- Invasive Measurement of the Absolute Hemoglobin Value in the Retinal Arteries of Anemic and Healthy Subjects Using a New Approach

The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries.

To our knowledge no tool exists that allows for direct collection of hemoglobin data in the eye. In many eye diseases (especially diabetic and hypertensive retinopathy as well as in retinal vessel occlusions) retinal circulation is modified. Knowing hemoglobin concentration on the site of the pathology will give us further information about the pathogenesis of this diseases and may provide a new possibility in therapy.

The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries. Healthy volunteers from the eye clinic and pregnant otherwise healthy patients of the gynecological department of the Triemli Hospital, Zurich, as well as anemic gynecological patients that show up for a check-up are included.

Hemoglobin will be quantified by a blood draw of a cubital vein. Using a Fundus Camera (Nidek AFC-230) pictures of the fundus will be taken from each study patient. Afterwards the study investigator selects a retinal artery of interest which will be used for measuring the hemoglobin concentration. Intensity of the green channel of the camera chip is determined with the aid of the law of Lambert-Beer.

Absolute Hemoglobin concentration is calculated in relation to the vessel volume.

Observational
Not Provided
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Non-Probability Sample

healthy subjects from the eye clinic of Triemli Hospital anemic and pregnant patients from the gynecology department, Triemli Hospital

  • Healthy Subjects
  • Anemia
Device: Fundus photography, cubital blood draw
blood draw from a cubital vein to measure hemoglobin concentration taking a fundus photography with a Nidek AFC-230, no pupil dilation needed
healthy volunteers, anemic patients
healthy volunteers from the eye and gynecology department pregnant patients with anemia
Intervention: Device: Fundus photography, cubital blood draw
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
June 2010
June 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy volunteers
  • pregnant patients from the Triemli Hospital that came for a routine check up
  • anemic patients of the same dept with various gynecological tumors

Exclusion Criteria:

  • any known retinal eye disease
  • poor fundus picture quality due to fixtion problems or too small pupil or media intransparency
  • not willing to participate in a study
Both
18 Years to 90 Years
Yes
Contact: Yves Robert, Prof MD +41 44 466 ext 3200 yves.robert@triemli.stzh.ch
Switzerland
 
NCT01025011
D20028132
No
Prof Yves Robert, Stadtpital Triemli (Triemli Hospital)
Triemli Hospital
Not Provided
Principal Investigator: Yves Robert, Prof MD Triemli Hospital
Triemli Hospital
November 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP