Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans (VINE)

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Bo Fernhall, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier:
NCT01024634
First received: December 2, 2009
Last updated: December 14, 2012
Last verified: December 2012

December 2, 2009
December 14, 2012
September 2009
July 2011   (final data collection date for primary outcome measure)
Arterial function [ Time Frame: Pre, following a 4 week control period and after 8 weeks of exercise intervention ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01024634 on ClinicalTrials.gov Archive Site
Autonomic function [ Time Frame: Pre, following a 4 week control period and following 8 weeeks of an exercise intervention ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans

The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians.

African-Americans are at greater risk than Caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. This is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity of resistance arteries in African-Americans. In addition, African-Americans have higher levels of inflammatory markers, and a greater sympathoexcitatory response to various stressors. This imbalance between sympathetic and reduced parasympathetic activation may directly affect vascular function and potentiate a greater inflammatory response, further altering key structural and functional properties of the vascular wall. The overall aim of this proposal is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians. We will examine these effects at rest and following a high intensity (maximal cycle ergometry) sympathoexcitation at both pre- and post-intervention time points, since sympathoexcitation may elucidate changes not evident at rest. Because African-Americans have higher levels of arterial stiffness, lower microvascular reactivity, greater responses to sympathoexcitation, greater levels of inflammatory markers and greater vasoconstrictive tone, we hypothesize that African-Americans will show differential responses to exercise training and benefit more compared to a matched group of Caucasians.

Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
  • Vascular Health
  • Autonomic Function
Behavioral: Endurance Exercise
8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session
  • African American Group
    A group of young African American males and females
    Intervention: Behavioral: Endurance Exercise
  • Caucasian Group
    a group of young Caucasian men and women
    Intervention: Behavioral: Endurance Exercise
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
91
December 2012
July 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded

Exclusion Criteria:

  • Subjects who smoke, are severely obese (body mass index > 35 kg/m2), or who have hypertension (blood pressure >140/90mmHg), diabetes (fasting glucose >110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded
Both
18 Years to 35 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01024634
UIUC 09599, 1R01HL093249-01A1
Yes
Bo Fernhall, University of Illinois at Urbana-Champaign
University of Illinois at Urbana-Champaign
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Bo Fernhall, Ph.D. University of Illinois at Urbana-Champaign
University of Illinois at Urbana-Champaign
December 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP