Adipogenic Capacity as a Mediator of Weight Gain

To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

• Other: Very Low Energy Diet (VLED)
  a VLED (Modifast) for 2 months in order to reduce body weight
  Other Name: Modifast
• Other: Weight maintenance
  10 months

• High predisposition
  High predisposition for weight regain
  Interventions:

  • Other: Very Low Energy Diet (VLED)
  • Other: Weight maintenance
• low predisposition
  low predisposition for weight regain
  Interventions:

  • Other: Very Low Energy Diet (VLED)
  • Other: Weight maintenance
• Medium predisposition
  Medium predisposition for weight regain
  Interventions:

  • Other: Very Low Energy Diet (VLED)
  • Other: Weight maintenance

Inclusion Criteria:

• BMI 28-35
• healthy, no medication
• no smoking
• stable weight (no weight loss/gain > 5kg in 3 months prior to study)

Exclusion Criteria:

• 28< BMI >35
• use of medication
• smoking
• weight loss/gain > 5kg in 3 months prior to study