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Adipogenic Capacity as a Mediator of Weight Gain

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2012 by Maastricht University Medical Center.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01015508
First received: November 17, 2009
Last updated: October 24, 2012
Last verified: October 2012

November 17, 2009
October 24, 2012
February 2010
November 2012   (final data collection date for primary outcome measure)
Energy expenditure [ Time Frame: 0, 2 and 12 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01015508 on ClinicalTrials.gov Archive Site
Adipogenic capacity, Physical activity and body composition [ Time Frame: 0, 2 and 12 months ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Adipogenic Capacity as a Mediator of Weight Gain
The Role of the Genetic Background Involved in Weight Regain Through Mechanisms Including Energy Expenditure, Physical Activity and Adipogenic Capacity

To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Supportive Care
Obesity
  • Other: Very Low Energy Diet (VLED)
    a VLED (Modifast) for 2 months in order to reduce body weight
    Other Name: Modifast
  • Other: Weight maintenance
    10 months
  • High predisposition
    High predisposition for weight regain
    Interventions:
    • Other: Very Low Energy Diet (VLED)
    • Other: Weight maintenance
  • low predisposition
    low predisposition for weight regain
    Interventions:
    • Other: Very Low Energy Diet (VLED)
    • Other: Weight maintenance
  • Medium predisposition
    Medium predisposition for weight regain
    Interventions:
    • Other: Very Low Energy Diet (VLED)
    • Other: Weight maintenance

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
200
November 2012
November 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • BMI 28-35
  • healthy, no medication
  • no smoking
  • stable weight (no weight loss/gain > 5kg in 3 months prior to study)

Exclusion Criteria:

  • 28< BMI >35
  • use of medication
  • smoking
  • weight loss/gain > 5kg in 3 months prior to study
Both
18 Years to 50 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Netherlands
 
NCT01015508
HumBio_Westerterp09
Yes
Maastricht University Medical Center
Maastricht University Medical Center
Not Provided
Principal Investigator: Klaas R Westerterp, Prof Maastricht University
Maastricht University Medical Center
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP