Detection and Quant of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using Positron Emission Tomography/Computed Tomography (PET/CT)

• Amount of lesional FDG uptake (assessed by qualitative assessment, standardized uptake value (SUV), and lesion to background uptake ratios) [ Time Frame: At 60 and 180 minutes after FDG administration ] [ Designated as safety issue: No ]
• Rate of change of lesional FDG uptake (measured by change in SUV) [ Designated as safety issue: No ]
• Characteristics of lesional SUV frequency histograms (e.g., mean, standard deviation, full-width-half-maximum (FWHM), etc.) and/or lesional SUV heterogeneity maps, along with changes in these characteristics [ Designated as safety issue: No ]

• Effect of lesion size (e.g., lesions = 3 cm) on primary outcome variables. [ Designated as safety issue: No ]
• Effect of lesion location on primary outcome variables (e.g., nodal vs extranodal) [ Designated as safety issue: No ]
• Effect of imaging delay time of PET image acquisition upon number of lymphomatous lesions detected [ Designated as safety issue: No ]

RATIONALE: Imaging procedures, such as positron emission tomography or computed tomography, may help in detecting differences between Hodgkin lymphoma or diffuse large B-cell lymphoma cancer cells. PURPOSE: This clinical trial is studying positron emission tomogaphy and computed tomography in determining differences in Hodgkin lymphoma and diffuse large B-cell lymphoma.

OBJECTIVES:

I. Assess the feasibility of detection and quantification of differences in the temporal and spatial distribution of FDG uptake between lesions of HL and DLBCL.

OUTLINE:

Patients undergo fludeoxyglucose F18 (FDG) positron emission tomography/computed tomography scans 60 and 180 minutes after FDG administration.

After completion of study, patients are followed for 24 hours.

• Radiation: Fludeoxyglucose F18
  Undergo FDG PET/CT scans
  Other Name: 18FDG, FDG, Fluorine-18, 2 Fluoro-2-deoxy-D-Glucose, Fludeoxyglucose F18
• Procedure: Computed Tomography
  Undergo FDG PET/CT scans
  Other Name: tomography, computed
• Procedure: Positron emission tomography
  Undergo FDG PET/CT scans
  Other Name: FDG-PET, PET, PET scan, tomography, emission computed

Inclusion Criteria:

• Subjects with a pathologically-proven diagnosis of classic HL or DLBCL with measurable disease by any imaging technique or physical examination.

Exclusion Criteria:

• Pregnant or nursing,
• Uncontrolled diabetes mellitus,
• Active infection,
• Inability to give informed consent or to comply with all study procedures,
• Subjects may be excluded at the discretion of the principal investigator or study team members.