TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2014 by Brigham and Women's Hospital
Sponsor:
Collaborators:
American Heart Association
Harvard Medical School
Information provided by (Responsible Party):
Jochen Daniel Muehlschlegel, MD, Brigham and Women's Hospital
ClinicalTrials.gov Identifier:
NCT00985049
First received: September 24, 2009
Last updated: April 15, 2014
Last verified: April 2014

September 24, 2009
April 15, 2014
March 2009
June 2016   (final data collection date for primary outcome measure)
Differential gene expression [ Time Frame: Immediate ] [ Designated as safety issue: No ]
Not Provided
Complete list of historical versions of study NCT00985049 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

DNA, EDTA , peripheral blood leucocytes, and left ventricle myocardium are all stored in -80C frreezer at BWH.

Non-Probability Sample

Adult patients undergoing cardiac surgery

Cardiovascular Diseases
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
200
December 2018
June 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Aged greater than 20 years
  • Undergoing aortic valve surgery with or without CABG surgery
  • Receive and apical vent as part of the surgery

Exclusion Criteria:

  • Will not receive an apical left ventricular vent
Both
20 Years and older
No
Contact: Jochen D Muehlschlegel, MD, MMSc 617-732-7330 jmuehlschlegel@partners.org
Contact: Simon C Body, MBChB MPH 617-732-7330 sbody@partners.org
United States
 
NCT00985049
2007p002323
No
Jochen Daniel Muehlschlegel, MD, Brigham and Women's Hospital
Brigham and Women's Hospital
  • National Institutes of Health (NIH)
  • American Heart Association
  • Harvard Medical School
Principal Investigator: Jochen D. Muehlschlegel, MD Brigham and Women's Hospital
Brigham and Women's Hospital
April 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP