Language Treatment for Progressive Aphasia

The recruitment status of this study is unknown because the information has not been verified recently.

Verified November 2010 by Baycrest.
Recruitment status was Active, not recruiting

Sponsor:

Collaborator:

Canadian Institutes of Health Research (CIHR)

Information provided by:

Baycrest

ClinicalTrials.gov Identifier:

NCT00957710

First received: August 11, 2009

Last updated: December 1, 2010

Last verified: November 2010

History of Changes

Tracking Information

First Received Date ^ICMJE

August 11, 2009

Last Updated Date

December 1, 2010

Start Date ^ICMJE

August 2009

Primary Completion Date

July 2010 (final data collection date for primary outcome measure)

Current Primary Outcome Measures ^ICMJE

Accuracy of picture naming [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

Complete list of historical versions of study NCT00957710 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Changes on neuroimaging [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Original Secondary Outcome Measures ^ICMJE

Same as current

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Language Treatment for Progressive Aphasia

Official Title ^ICMJE

Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study

Brief Summary

Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. The aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. The first goal of this study is to improve naming abilities of individuals with progressive aphasia. This will be accomplished by carrying out an intensive treatment program for anomia. The second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional Magnetic Resonance Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging tractography (to measure the connectivity between specific brain regions). This is the first study on progressive aphasia addressing both treatment and imaging in the same patients.

Detailed Description

Not Provided

Study Type ^ICMJE

Interventional

Study Phase

Not Provided

Study Design ^ICMJE

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label

Condition ^ICMJE

Primary Progressive Aphasia
Nonfluent Progressive Aphasia
Semantic Dementia

Intervention ^ICMJE

Behavioral: Errorless learning

Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls

Other Name: treatment for anomia

Study Arm (s)

Experimental: langauge therapy

Intervention: Behavioral: Errorless learning

Publications *

Jokel R, Rochon E, Anderson ND. Errorless learning of computer-generated words in a patient with semantic dementia. Neuropsychol Rehabil. 2009 May 19;:1-26 [Epub ahead of print]
Jokel R, Rochon E, Leonard C. Treating anomia in semantic dementia: improvement, maintenance, or both? Neuropsychol Rehabil. 2006 Jun;16(3):241-56.
Jokel R, Rochon E, Leonard C. Therapy for anomia in semantic dementia. Brain Cogn. 2002 Jul;49(2):241-4.
Jokel R, Cupit J, Rochon E, Leonard C. Relearning lost vocabulary in nonfluent progressive aphasia with Mosstalk Words. Aphasiology 23(2): 175-191, 2009

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Active, not recruiting

Estimated Enrollment ^ICMJE

Estimated Completion Date

December 2010

Primary Completion Date

July 2010 (final data collection date for primary outcome measure)

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Diagnosis of progressive aphasia
Native English speaker or fluent in English
Adequate hearing and vision (not requiring more than +6 diopter correction)
Willing and able to participate in each phase of the study (including two fMRI sessions)

Exclusion Criteria:

Contraindications to fMRI (e.g., claustrophobia, pacemaker, ferromagnetic implant)
Current medical or psychiatric condition affecting cognition (other than progressive aphasia)

Gender

Both

Ages

40 Years to 80 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Canada

Administrative Information

NCT Number ^ICMJE

NCT00957710

Other Study ID Numbers ^ICMJE

REB 09-24

Has Data Monitoring Committee

Responsible Party

Regina Jokel, Baycrest

Study Sponsor ^ICMJE

Baycrest

Collaborators ^ICMJE

Canadian Institutes of Health Research (CIHR)

Investigators ^ICMJE

Principal Investigator:

Regina Jokel, PhD

Baycrest

Information Provided By

Baycrest

Verification Date

November 2010

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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