Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2010 by The University of Hong Kong.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
The University of Hong Kong
ClinicalTrials.gov Identifier:
NCT00957463
First received: August 10, 2009
Last updated: July 1, 2010
Last verified: July 2010

August 10, 2009
July 1, 2010
June 2008
December 2010   (final data collection date for primary outcome measure)
reactive hyperemia induced peripheral arterial tone (RH-RAT) index [ Time Frame: baseline ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00957463 on ClinicalTrials.gov Archive Site
circulatory metabolic and vascular inflammatory biomarkers [ Time Frame: baseline ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function
Effects of Intermittent Hypoxia and/or Cigarette Smoking on Endothelial Injury in Vivo - Relevance to Obstructive Sleep Apnea

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample

Consecutive subjects who undergo polysomnograms (PSG) in the Sleep Disorder Centre, Department of Medicine, Queen Mary Hospital, and who fulfill the study criteria will be recruited.

  • Obstructive Sleep Apnea
  • Smoking
Not Provided
  • smoker, with high apnea-hypopnea index
    subjects who smoke either in the past or currently, with confirmed moderate-severe OSA
  • smoker, mild OSA or without OSA
    subjects who smoke either in the past or currently, with mild OSA or without OSA
  • nonsmoker, with high apnea-hypopnea index
    subjects who never smoke, with confirmed moderate-severe OSA
  • nonsmoker, with mild OSA or without OSA
    subjects who never smoke, with mild OSA or without OSA

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
150
Not Provided
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • No acute illness
  • No hospitalization in past 4 weeks
  • Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion Criteria:

  • Mentally incapacitated
Both
18 Years and older
No
Contact: Mary SM Ip, MD 852-28554455 msmip@hkucc.hku.hk
Contact: Macy MS Lui, MRCP 852-73069288 macylui@graduate.hku.hk
Hong Kong
 
NCT00957463
UW 08-023
Not Provided
Professor Mary SM Ip, The University of Hong Kong
The University of Hong Kong
Not Provided
Principal Investigator: Mary SM Ip, MD The University of Hong Kong
The University of Hong Kong
July 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP