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Study of Blood Samples From Patients With Osteosarcoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by National Cancer Institute (NCI).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00954473
First received: August 6, 2009
Last updated: August 8, 2009
Last verified: August 2009
History of Changes

August 6, 2009
August 8, 2009
January 2009
Not Provided
Gene associations [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00954473 on ClinicalTrials.gov Archive Site
  • Genome-wide associations [ Designated as safety issue: No ]
  • Genomic regions associated with osteosarcoma [ Designated as safety issue: No ]
  • Functional implications of promising genetic variants associated with osteosarcoma [ Designated as safety issue: No ]
Same as current
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Study of Blood Samples From Patients With Osteosarcoma
Retrospective Study of Genetic Risk Factors for Osteosarcoma

RATIONALE: Studying the genes found in samples of blood from patients with osteosarcoma may help doctors identify biomarkers related to the disease.

PURPOSE: This research study is looking at blood samples from patients with osteosarcoma.

OBJECTIVES:

Primary

  • Conduct a large-scale candidate gene-association study in patients with osteosarcoma using cases from clinical trials COG-P9851 and COG-AOST06B1.

Secondary

  • Conduct a genome-wide association study of osteosarcoma.
  • Fine-map genomic regions associated with osteosarcoma to identify putative functional loci.
  • Investigate the functional implications of promising genetic variants associated with osteosarcoma.

OUTLINE: This is a multicenter study.

Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.
Observational
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Sarcoma
  • Genetic: polymorphism analysis
  • Other: laboratory biomarker analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
1000
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DISEASE CHARACTERISTICS:

  • Blood samples collected from clinical trials COG-P9851 and COG-AOST06B1

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
Both
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No
Contact information is only displayed when the study is recruiting subjects
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NCT00954473
CDR0000633101, COG-AOST08B1
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Children's Oncology Group
National Cancer Institute (NCI)
Study Chair: Sharon A. Savage, MD National Cancer Institute - EPN
National Cancer Institute (NCI)
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP