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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Huashan Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Huashan Hospital
ClinicalTrials.gov Identifier:
NCT00953992
First received: August 5, 2009
Last updated: June 9, 2010
Last verified: August 2009
History of Changes

August 5, 2009
June 9, 2010
April 2009
December 2011   (final data collection date for primary outcome measure)
renal function survival rate days in the hospital days in the ICU [ Time Frame: discharg from hospital, 28days,90days ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT00953992 on ClinicalTrials.gov Archive Site
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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)
The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
  • To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
  • To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
  • To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

  1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI

    - Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."

  2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
  3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:

1ml whole blood and 1ml serum will obtained within 24 hour after AKI for hematological and biochemistry analyze.
Non-Probability Sample

Patients selected from a university-affiliated hospital in Shanghai, China.
  • Renal Failure
  • Nutrition
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
300
August 2012
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age >=16 years and <= 88 years
  • clinically diagnosed with acute kidney injury, according RIFLE criteria.

Exclusion Criteria:

  • acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
  • Do Not Resuscitate (DNR) status
  • subjects enrolled in another clinical trial that could affect the outcome of this study protocol
Both
16 Years to 88 Years
No
Contact: Feng Ding, professor 86-02152888135 ding_feng@hotmail.com
China
 
NCT00953992
KY2009-107
Yes
Feng Ding, Huashan hospital
Huashan Hospital
Not Provided
Principal Investigator: Feng Ding, professor Huashan Hospital
Huashan Hospital
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP