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Oxygen Concentration Should be Kept at the Lowest Possible Level During Recruitment

This study has been completed.
Sponsor:
Information provided by:
Istanbul University
ClinicalTrials.gov Identifier:
NCT00944086
First received: July 21, 2009
Last updated: August 3, 2009
Last verified: August 2009

July 21, 2009
August 3, 2009
May 2008
August 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00944086 on ClinicalTrials.gov Archive Site
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Oxygen Concentration Should be Kept at the Lowest Possible Level During Recruitment
A Prospective Randomized Clinical Study:Oxygen Concentration Should be Kept at the Lowest Possible Level During Recruitment Manoeuvres

In This Study, Our Goal is to Compare the Effects of Recruitment Manoeuvre Which is Applied With Different Oxygen Concentrations on Oxygenation and Respiratory Mechanics During Pneumoperitoneum

Detailed Description:

"Recruitment manoeuvre" which has been defined and become popular in the recent years is nowadays widely accepted and applied. The positive effects of the recruitment manoeuvre during and after surgery on respiratory mechanics and oxygenation have been reported. The duration and the applied pressure values of recruitment manoeuvre have been defined well and in detail regarding the definitions for this manoeuvre (1-3). Despite these definitions, no detailed information has been provided on the effects of the oxygen and oxygen concentration during recruitment manoeuvre .

Atelectasis develops after the induction of anaesthesia, even in healthy subjects, and is associated with an increase in intraoperative shunt leading to impairment of gas exchange (4). It is well known that in patients, who have undergone mechanical ventilation with high oxygen concentration levels, oxygen replaces the less insoluble nitrogen. Partial oxygen pressure increases with the implementation of oxygen in high concentrations, and the oxygen flow into the blood increases. But when the gas flow into the blood is more than inspired, absorption atelectasis develops in lungs - due to appliance of high oxygen concentration. Atelectasis may also develop due to different reasons such as failure in secretion clearance during the surgery, replacement of nitrogen with inhalation anaesthetics and appliance of pneumoperitoneum.

In the recent years, many studies have analyzed the effects of recruitment manoeuvre during pneumoperitoneum and laparoscopic surgery on respiratory mechanics and oxygenation, and reported the benefits of recruitment in these operations (4-6).

In this study, our goal is to compare the effects of recruitment manoeuvre which is applied with different oxygen concentrations on oxygenation and respiratory mechanics during pneumoperitoneum.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Probability Sample

This study has been applied on 32 cases which have undergone laparoscopic cholecystectomy.

Laparoscopic Surgery
Other: Recruitment Manoeuvre
Recruitment Manoeuvre
Recruitment Manoeuvre ,Laparoscopy
Intervention: Other: Recruitment Manoeuvre
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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August 2008
August 2008   (final data collection date for primary outcome measure)

Exclusion Criteria:

  • Patients, who were older than 65 years,
  • had respiratory system and cardiovascular diseases,
  • used medication that could affect the respiratory function or smokers have been excluded.
Both
27 Years to 61 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Turkey
 
NCT00944086
Akaratas
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Istanbul University
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Istanbul University
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP