A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by:
National University Hospital, Singapore
ClinicalTrials.gov Identifier:
NCT00943891
First received: July 20, 2009
Last updated: January 21, 2014
Last verified: January 2014

July 20, 2009
January 21, 2014
July 2008
December 2014   (final data collection date for primary outcome measure)
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Not Provided
Complete list of historical versions of study NCT00943891 on ClinicalTrials.gov Archive Site
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A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
  1. To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens
  2. To determine the association between VEGF-C,-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
  3. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods.
Not Provided
Observational
Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
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Retention:   Samples With DNA
Description:

CRC and NPC tumor specimens will be obtained.

Non-Probability Sample

Colorectal and nasopharyngeal cancer.

  • Colorectal Cancer
  • Nasopharyngeal Cancer
Procedure: Tumor biopsies
Tumor biopsies
Intervention: Procedure: Tumor biopsies

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
500
December 2014
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male and female patients are eligible
  • Patients 21 years or older

Exclusion Criteria:

  • None
Both
21 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Singapore
 
NCT00943891
MC01/09/08
No
Not Provided
National University Hospital, Singapore
Not Provided
Principal Investigator: Ross Andrew Soo, MBBS National University Hospital, Singapore
National University Hospital, Singapore
January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP