Predictors of Cord Blood Immunoglobin E (IgE) Levels

The recruitment status of this study is unknown because the information has not been verified recently.

Verified May 2009 by Min-Sheng General Hospital.
Recruitment status was Recruiting

Sponsor:

Information provided by:

Min-Sheng General Hospital

ClinicalTrials.gov Identifier:

NCT00902096

First received: May 13, 2009

Last updated: NA

Last verified: May 2009

History: No changes posted

Tracking Information

First Received Date ^ICMJE

May 13, 2009

Last Updated Date

May 13, 2009

Start Date ^ICMJE

April 2009

Primary Completion Date

Not Provided

Current Primary Outcome Measures ^ICMJE

cord blood IgE [ Time Frame: at birth ] [ Designated as safety issue: No ]

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

No Changes Posted

Current Secondary Outcome Measures ^ICMJE

Cord blood cytokines or other mediators [ Time Frame: at birth ] [ Designated as safety issue: No ]

Original Secondary Outcome Measures ^ICMJE

Same as current

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Predictors of Cord Blood Immunoglobin E (IgE) Levels

Official Title ^ICMJE

Not Provided

Brief Summary

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.

Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.

Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.

Detailed Description

Not Provided

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Cohort
Time Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Not Provided

Sampling Method

Non-Probability Sample

Study Population

hospital and primary care clinic based study

Condition ^ICMJE

Atopy

Intervention ^ICMJE

Not Provided

Study Group/Cohort (s)

Prenatal factors

Prenatal factors to predict cord blood IgE

Publications *

Not Provided

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Recruiting

Estimated Enrollment ^ICMJE

800

Completion Date

Not Provided

Primary Completion Date

Not Provided

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Mothers in pregnancy 18 years of age or older, AND
Mothers able to speak Chinese.

Exclusion Criteria:

Infant delivered at less than 36 weeks' gestation,
Infant with Apgar score in 5 minutes after birth < 7,
Infant with a major congenital anomaly, OR
Infant admitted to an intensive care unit.

Gender

Both

Ages

Not Provided

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact: Chien-Han Chen, MD

886-3-3179599 ext 2004

chinsword@yahoo.com.tw

Location Countries ^ICMJE

Taiwan

Administrative Information

NCT Number ^ICMJE

NCT00902096

Other Study ID Numbers ^ICMJE

2009008

Has Data Monitoring Committee

Not Provided

Responsible Party

Chien-Han Chen, Min-Sheng General Hospital

Study Sponsor ^ICMJE

Min-Sheng General Hospital

Collaborators ^ICMJE

Not Provided

Investigators ^ICMJE

Principal Investigator:

Chien-Han Chen, MD

Min-Sheng General Hospital

Information Provided By

Min-Sheng General Hospital

Verification Date

May 2009

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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