Study of Stored Tumor Samples in Young Patients With Brain Tumors

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by St. Jude Children's Research Hospital
Sponsor:
Information provided by (Responsible Party):
St. Jude Children's Research Hospital
ClinicalTrials.gov Identifier:
NCT00897286
First received: May 9, 2009
Last updated: February 3, 2014
Last verified: February 2014

May 9, 2009
February 3, 2014
November 2004
November 2014   (final data collection date for primary outcome measure)
Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Time Frame: 10 Years ] [ Designated as safety issue: No ]
Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00897286 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Study of Stored Tumor Samples in Young Patients With Brain Tumors
Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS

This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

The overall objective of this non-therapeutic protocol is to identify molecular abnormalities within prospectively treated pediatric CNS Atypical Teratoid Rhabdoid Tumors (ATRT), Choroid Plexus Carcinomas (CPC), and Ependymoma tumors and define the relationship between these abnormalities and tumor histologic and clinical characteristics. This objective will be achieved by applying state-of-the-art DNA, RNA and protein analysis tools to the study of fresh frozen, fixed and cultured tumor cells. The establishment of cell cultures from each tumor sample will also allow for in vitro analysis of tumor cell growth, signaling and therapeutic response.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Fresh frozen, fixed and cultured tumor cells collected prospectively from a clinically well characterized patient cohort.

Non-Probability Sample

Participants will have ATRT, CPC, medulloblastoma/PNET or ependymoma of the CNS as documented by the local neuropathologist. All studies will be conducted using tumor material collected prospectively from a clinically well characterized patient cohort.

Brain and Central Nervous System Tumors
Not Provided
Tumor/Tissue Sample
Tumor material collected prospectively from a clinically well characterized patient cohort
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
200
November 2014
November 2014   (final data collection date for primary outcome measure)

Inclusion Criteria

  • ATRT, CPC, medulloblastoma/PNET or ependymoma of the CNS as documented by the local neuropathologist. Tumor may be primary, progressive or relapsed disease.
  • Age not more than 21 years at the time of initial diagnosis.
  • Enrollment in the current version of the institution's banking protocol

Exclusion Criteria

  • Diagnosis other than ATRT, CPC, medulloblastoma/PNET or ependymoma of the central nervous system.
  • Age greater than 21 years at the time of diagnosis
Both
up to 21 Years
No
Contact: Tabatha E. Doyle, RN 901-595-2544 tabatha.doyle@stjude.org
United States
 
NCT00897286
NBTP01
No
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Not Provided
Principal Investigator: Amar Gajjar, MD St. Jude Children's Research Hospital
Principal Investigator: Richard J. Gilbertson, MD, PhD St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
February 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP