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Hepatic Mitochondrial Function in Sepsis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Institut d'Anesthesiologie des Alpes Maritimes.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Institut d'Anesthesiologie des Alpes Maritimes
ClinicalTrials.gov Identifier:
NCT00889083
First received: April 24, 2009
Last updated: June 30, 2011
Last verified: June 2011

April 24, 2009
June 30, 2011
April 2009
April 2012   (final data collection date for primary outcome measure)
Mitochondrial complex activities [ Time Frame: during surgery ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00889083 on ClinicalTrials.gov Archive Site
  • Quantification of adenine nucleotides [ Time Frame: during surgery ] [ Designated as safety issue: No ]
  • Quantification of oxidative stress markers [ Time Frame: during surgery ] [ Designated as safety issue: No ]
  • Correlation between SOFA score and mitochondrial complex activities [ Time Frame: 28 days ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Hepatic Mitochondrial Function in Sepsis
Evaluation of Hepatic Mitochondrial Function in Sepsis

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Liver biopsies

Non-Probability Sample

Community sample

  • Sepsis
  • Peritonitis
Not Provided
  • Control
    Non septic patients needing hepatic surgery
  • Sepsis
    Septic patients needing surgery for peritonitis

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
60
April 2012
April 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Septic group : Peritonitis patients needing surgery
  • Non septic group : Patients needing hepatic surgery

Exclusion Criteria:

  • No liver biopsy performed
Both
18 Years to 80 Years
No
Contact: Jean-Christophe Orban, MD 0033611947008 orban.j@chu-nice.fr
Contact: Carole Ichai, MD, PhD carole.ichai@unice.fr
France
 
NCT00889083
IAAM-2009-1
No
Jean-Christophe Orban, CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
Not Provided
Study Chair: Carole Ichai, MD, PhD CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP