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Autonomic Nervous Activity in Women With Gestational Diabetes

This study has been completed.
Sponsor:
Information provided by:
Helsinki University
ClinicalTrials.gov Identifier:
NCT00867022
First received: March 20, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

March 20, 2009
March 20, 2009
August 2004
November 2007   (final data collection date for primary outcome measure)
Serum Noradrenalin level [ Designated as safety issue: No ]
Same as current
No Changes Posted
Heart rate variability: LF, VLF, HF [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Autonomic Nervous Activity in Women With Gestational Diabetes
Autonomic Nervous Activity in Women With Gestational Diabetes

Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Gestational diabetic women having or not hypertension with two control groups, one pregnant on non-pregnant. All the women are studied during night time to study the arousal of the sympathetic activity in the early morning hours

Gestational Diabetes
Not Provided
  • 1
    Women with gestational diabetes
  • 2
    Pregnant women without gestational daibetes
  • 3
    Women with gestational diabetes and hypertension
  • 4
    Non pregnant women
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
March 2009
November 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of gestational diabetes (OGTT) with or without BP > 140/90.
  • Pregnant control with normal OGTT-

Exclusion Criteria:

  • Smoking
  • Uncontrolled hypertension
  • Diabetes
  • Medication affecting sympathetic activity
Female
18 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Finland
 
NCT00867022
GESTSYMPIS
No
Risto Kaaja, Helsinki University Hospital
Helsinki University
Not Provided
Not Provided
Helsinki University
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP