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Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

This study has been completed.
Sponsor:
Collaborators:
The Danish Obesity Research Centre
Nordic Centre of Excellence
Information provided by:
Aarhus University Hospital
ClinicalTrials.gov Identifier:
NCT00863564
First received: March 17, 2009
Last updated: November 9, 2009
Last verified: November 2009
History of Changes

March 17, 2009
November 9, 2009
March 2009
October 2009   (final data collection date for primary outcome measure)
Triglyceride [ Time Frame: 0h- 2h- 4h- 6h- 8h postprandial ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00863564 on ClinicalTrials.gov Archive Site
  • Incretins [ Time Frame: 0h -1h -2h -4h -6h -8h Postprandial ] [ Designated as safety issue: No ]
  • Inflammatory markers [ Time Frame: 0h- 1h- 2h- 4h- 6h- 8h postprandial ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects
Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
  • Obesity
  • Postprandial Lipemia
  • Atherosclerosis
  • Inflammation
  • Postprandial Incretins
  • Dietary Supplement: Caseine
  • Dietary Supplement: Cod
  • Dietary Supplement: Gluten
  • Dietary Supplement: Whey Isolate
  • Active Comparator: Whey Isolate
    Intervention: Dietary Supplement: Whey Isolate
  • Active Comparator: Caseine
    Intervention: Dietary Supplement: Caseine
  • Active Comparator: Cod
    Intervention: Dietary Supplement: Cod
  • Active Comparator: Gluten
    Intervention: Dietary Supplement: Gluten
Holmer-Jensen J, Karhu T, Mortensen LS, Pedersen SB, Herzig KH, Hermansen K. Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J. 2011 Oct 19;10:115.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
12
October 2009
October 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • BMI > 30 kg/m2 & < 45 kg/m2

Exclusion Criteria:

  • Diabetes
  • Lipid lowering drugs
  • Liver-, Kidney- and/or Heart Disease
  • Serious Hypertension (160/110)
Both
40 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00863564
CERN-PPL-JHJ-5a
No
Kjeld Hermansen, Professor, Chief Physician, MD, Dr.Med.Sci, Department of Endocrinology And Metabolism, Aarhus University Hospital
Aarhus University Hospital
  • The Danish Obesity Research Centre
  • Nordic Centre of Excellence
Principal Investigator: K Hermansen, Professor, MD Department of Endocrinology and Metabolism, Aarhus University Hospital
Aarhus University Hospital
November 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP