Impairments of Oral Language in Mobius Syndrome

This study has been completed.
Sponsor:
Information provided by:
Fortaleza University
ClinicalTrials.gov Identifier:
NCT00856531
First received: March 4, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

March 4, 2009
March 4, 2009
January 2002
January 2003   (final data collection date for primary outcome measure)
Not Provided
Not Provided
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Impairments of Oral Language in Mobius Syndrome
Impairments of Oral Language in Subjects With the Möbius Sequence

The Möbius syndrome constitutes a congenital disorder classically caused by genetic and environmental factors. The clinical manifestations include lesion of the facial and abducens nerves associated with limb malformations specially club foot. The speech-language manifestations include compromise of oral and deglutition, speech and language functions, secondary to cranial nerves lesions and mental retardation. The language compromise in this disorder is still not well known. In this way, the main objective of this study is to characterize the oral language in a population of fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará. The present work is a descriptive study of a cross-sectional design conducted from February to December/2002, using a clinical evaluation of language components including morphology, syntax, semantics and pragmatics. The investigators identified exclusive speech involvement in 20,0% of the subjects, language disturbance in 46,7%, speech and language disturbance in 13,3% and oral language involvement in 26,7%. The investigators conclude that the language disturbance in the Möbius syndrome presents with a variable compromise of all oral language components. The delay in linguistical development, incomprehensive speech and the deficit of constructions of sentences and narrations are constant.

In this way, the main objective of this study is to characterize the oral language in a population of fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará. The present work is a descriptive study of a cross-sectional design conducted from February to December/2002, using a clinical evaluation of language components including morphology, syntax, semantics and pragmatics.

Observational
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará, Brazil.

Möbius Sequence
Not Provided
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
  • 11
  • 12
  • 13
  • 14
  • 15
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
January 2003
January 2003   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Möbius syndrome
  • Age ranging from two to thirteen years old.

Exclusion Criteria:

  • Others diseases with impact in oral language.
Both
3 Years to 16 Years
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00856531
mobius syndrome
No
Renata Cavalcante Barbosa Haguette, Hospital Infantil Albert Sabin
Fortaleza University
Not Provided
Not Provided
Fortaleza University
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP