Text Size

Heart Rate Variability During Weaning From Mechanical Ventilation

This study has been completed.
Sponsor:
Information provided by:
Hospital de Clinicas de Porto Alegre
ClinicalTrials.gov Identifier:
NCT00851825
First received: February 25, 2009
Last updated: May 7, 2009
Last verified: May 2009
History of Changes

February 25, 2009
May 7, 2009
March 2003
Not Provided
heart rate variability analysis [ Time Frame: minutes ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT00851825 on ClinicalTrials.gov Archive Site
Cardiorespiratory variables [ Time Frame: minutes ] [ Designated as safety issue: Yes ]
Cardiorrespiratory variables [ Time Frame: minutes ] [ Designated as safety issue: Yes ]
Not Provided
Not Provided
 
Heart Rate Variability During Weaning From Mechanical Ventilation
The Effect of T-Tube and Pressure Support on Cardiorespiratory Variables and Heart Rate Variability During Weaning From Mechanical Ventilation

The discontinuation of mechanical ventilation (MV) and the recovery of spontaneous breathing can lead to important cardiovascular alterations due to changes in the intrathoracic pressure. The autonomic modulation assessed through heart rate variability (HRV) during weaning from MV and its impact on cardiorespiratory variables has not been well elucidated yet. To evaluate the effect of T-tube (TT) and pressure support ventilation (PSV) during weaning from MV on cardiorespiratory variables and heart rate variability.

Thirty patients who had received MV for ≥ 48 hours and who met the criteria for weaning were assessed. Two different weaning methods were used and randomization was performed to choose one of the following sequences (baseline, PSV, rest, TT; or baseline, TT, rest, PSV). HRV was assessed by heart rate spectral analysis during MV, PSV, and TT. Each intervention lasted 30 minutes and there was a 30-minute rest period between the interventions. At the end of each period of time, the following cardiorespiratory variables were analyzed: respiratory rate (f), minute ventilation (VE), tidal volume (VT), rapid shallow breathing index (f/VT), peripheral oxygen saturation (SpO2), heart rate (HR) and blood pressure. In the HRV, the total spectral power (TP), the low frequency (LF) and the high frequency (HF) components, and the ratio between the low/high frequency (LF/HF) components were calculated.
Observational
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

Patients with respiratory failure receiving MV for more than 48 hours, who had been admitted to the Intensive Care Unit (ICU) of the Hospital de Clínicas de Porto Alegre, and who met the criteria for weaning from MV according to the parameters previously defined were selected to participate in this study.
  • Critical Care
  • Weaning
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
June 2007
Not Provided

Inclusion Criteria:

  • Patients with respiratory failure receiving MV for more than 48 hours
  • for weaning from MV according to the parameters previously defined were selected to participate in this study

Exclusion Criteria:

  • arterial hypotension (systolic blood pressure < 100mmHg), severe brain disease, barotraumas, presence of thoracic drain or tracheostomy, using vasoactive and sedative drugs
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT00851825
03-435
No
Silvia Regina Rios Vieira, Hospital de Clinicas de Porto Alegre
Hospital de Clinicas de Porto Alegre
Not Provided
Principal Investigator: Silvia R Veira, PhD Hospital de Clínicas de Porto Alegre
Hospital de Clinicas de Porto Alegre
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP