Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum
ClinicalTrials.gov Identifier:
NCT00849914
First received: February 20, 2009
Last updated: October 15, 2012
Last verified: October 2012

February 20, 2009
October 15, 2012
July 2008
February 2009   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00849914 on ClinicalTrials.gov Archive Site
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Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer
Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Punch biopsy from tumour, punch biopsy from healthy skin

Non-Probability Sample

dermatologic primary care clinic

Skin Cancer
Not Provided
  • 1
    Patients with actinic keratoses of the skin
  • 2
    Patients with basal cell carcinoma of the skin
  • 3
    Patients with squamous cell carcinoma of the skin
Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, Bechara FG. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010 Jul;28(6):649-53. doi: 10.3109/07357901003630918.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
28
February 2009
February 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin

Exclusion Criteria:

  • Patients under 18 years of age
  • Patients with other forms of cancer in previous medical history
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT00849914
005
No
Michael Sand, Ruhr University of Bochum
Ruhr University of Bochum
Not Provided
Principal Investigator: Prof. Dr. Peter Altmeyer Department of Dermatology and Allergology, Ruhr-University Bochum
Ruhr University of Bochum
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP