Interactions Between Physical Activity and Cannabis Use in Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Maciej Buchowski, Vanderbilt University
ClinicalTrials.gov Identifier:
NCT00838448
First received: January 23, 2009
Last updated: June 11, 2013
Last verified: June 2013

January 23, 2009
June 11, 2013
January 2009
January 2011   (final data collection date for primary outcome measure)
Craving for cannabis [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00838448 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Interactions Between Physical Activity and Cannabis Use in Adults
Interactions Between Physical Activity and Cannabis Use in Adults

In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in cannabis users and compare results with results from controls. The investigators hypothesize that the regional brain activation in response to visual cues (pictures related to cannabis use and food) will be different in cannabis users than in controls and that exercise will significantly alter brain responses to the cues.

It is unknown how the response of cannabis users might compare to those of non-users in response to similar dose of physical activity. We will therefore compare brain activation during craving to cannabis, a natural reward (food) and a neutral scene (nature images). The food cues will allow us to determine if effects of exercise on brain activation and craving generalize to two different reward conditions and the nature scenes provide a neutral, no rewarding control. In addition to the analysis of predetermined regions of interest, whole-brain exploratory analyses will also be conducted to examine for additional brain regions showing associations between various conditions of interest and regional brain activation.

Specific Aims

1. To explore methodological factors involved in finding the relationship between PA and cannabis use.

  1. to examine the effects of cannabis and food cues on brain activation and craving in cannabis users and nonusers
  2. to examine the effects of vigorous exercise on brain activation and craving in response to cannabis and food cues.

Our working hypothesis is that the regional brain activation in response to drug cues will be different in cannabis users than in controls and that exercise will significantly alter brain responses to these cues in both groups. Our secondary hypothesis is that exercise will tend to normalize the abnormal brain activation observed in cannabis users.

Our expectation is that exercise will alter cue-responding in terms of brain activation or craving. It is possible that exercise may be a useful treatment in cannabis dependence. Future studies may examine this specific relationship.

There are no reports available exploring the relationship between physical activity and cannabis use.

Current data suggest that there are convergent findings regarding the chronic and acute effects of cannabis on brain activity

Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Cannabis Dependence
Behavioral: Exercise
Exercise performed on a treadmill for 20-30 minutes
  • Experimental: Cannabis users
    Cannabis users
    Intervention: Behavioral: Exercise
  • Experimental: Cannabis no-users
    Cannabis no-users
    Intervention: Behavioral: Exercise

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
June 2013
January 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Cases and Controls must:

    • Be able to understand the study and provide written informed consent.
    • Be male or female 18 -35 years of age.
    • Be in generally good health
    • If female of childbearing potential, have a negative serum pregnancy test on study day

Cases must:

  • Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
  • Not currently seeking treatment for cannabis dependence.
  • Have a positive urine drug test for cannabis on the study day
  • Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.

Exclusion Criteria:

  • Cases and Controls must not:

    • Be pregnant or lactating
    • Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
    • Have non-secure metallic foreign bodies
    • Have met criteria for another axis 1 diagnosis in the past 6 months
    • Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
    • Have chronic medical illness
    • Have epilepsy
    • Have a history of head injury that required hospitalization
    • Have claustrophobia
    • Have orthopedic or other problems precluding them from performing exercise protocol
    • Have body mass index (BMI) less than 19 kg/m2
    • Weighing more than 275 pounds (MRI table limit)

Cases must not:

  • Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
  • Have any serious medical or psychiatric illnesses and/or clinically significant symptoms, which in the judgment of the PI or his/her designee would make them unsafe, or would make compliance with the study protocol difficult or put the study staff at undue risk
Both
18 Years to 35 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00838448
081302
Yes
Maciej Buchowski, Vanderbilt University
Vanderbilt University
Not Provided
Principal Investigator: Maciej S Buchowski, Ph.D. Vanderbilt University
Vanderbilt University
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP