Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

This study has been completed.
Sponsor:
Collaborators:
Lundbeck Foundation
Team Denmark
Danish Ministry of Culture
Anti Doping Danmark
The Danish Rheumatism Association
King Christian IX and Queen Louise Jubilee Bursary
Information provided by:
Bispebjerg Hospital
ClinicalTrials.gov Identifier:
NCT00832663
First received: January 29, 2009
Last updated: March 15, 2010
Last verified: March 2010

January 29, 2009
March 15, 2010
April 2009
December 2009   (final data collection date for primary outcome measure)
Muscle regeneration [ Time Frame: 1 month ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00832663 on ClinicalTrials.gov Archive Site
Muscle strength [ Time Frame: 1 month ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration
The Influence of Blocking Inflammatory Activity in Vivo on Skeletal Muscle Regeneration in Humans

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Muscle Damage
  • Drug: NSAID
    Effect of NSAID ingestion on muscle regeneration
  • Drug: placebo
    receive placebo
  • Experimental: NSAID
    receive NSAID
    Intervention: Drug: NSAID
  • Placebo Comparator: Placebo
    receive placebo
    Intervention: Drug: placebo
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
32
December 2009
December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • male
  • healthy
  • does not exercise regularly

Exclusion Criteria:

  • displays contraindications for taking NSAID
  • well-trained
Male
18 Years to 35 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00832663
AM_P64_BBH, H-D-2008-074
No
Abigail Mackey, Institute of Sports Medicine Copenhagen
Bispebjerg Hospital
  • Lundbeck Foundation
  • Team Denmark
  • Danish Ministry of Culture
  • Anti Doping Danmark
  • The Danish Rheumatism Association
  • King Christian IX and Queen Louise Jubilee Bursary
Principal Investigator: Abigail L Mackey, PhD Institute of Sports Medicine Copenhagen, Bispebjerg Hospital
Bispebjerg Hospital
March 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP