Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

This study has been completed.
Sponsor:
Collaborators:
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinusfonden,
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00818506
First received: January 6, 2009
Last updated: November 20, 2012
Last verified: November 2012

January 6, 2009
November 20, 2012
March 2009
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Complete list of historical versions of study NCT00818506 on ClinicalTrials.gov Archive Site
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Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Retention:   Samples With DNA
Description:

Whole Blood

Probability Sample

Psychiatric treatment facilities (e.g. psychiatric hospital, private psychiatrist).

  • Depression
  • Major Depressive Disorder
  • Cardiovascular Disease
  • Coronary Artery Disease
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  • Late onset MDD
    Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.
  • Controls
    Healthy controls (matched for age, sex, and tobacco use status)
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
55
June 2012
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INCLUSION CRITERIA:

  • Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
  • Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
  • Age 50-70 years.
  • Written informed consent.
  • Caucasian.

EXCLUSION CRITERIA:

  • Known, or anamnestic/objective signs of, organic brain disease.
  • Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
  • Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
  • Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
  • Subject to force of law according to the danish law on psychiatry.
  • Present risk of suicide.
  • Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
  • Medical history of renal failure.
  • Other conditions which contraindicate specific procedures in the project.
  • Other conditions deemed to prevent the subject from completing the examination program.
  • Does not want to participate.
Both
50 Years to 70 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00818506
CPF-TAD-1
No
University of Aarhus
University of Aarhus
  • The Ministry of Science, Technology and Innovation, Denmark
  • Vejle Hospital
  • Danish National Research Foundation
  • Aarhus University Hospital
  • Augustinusfonden,
Study Director: Poul Videbech, Professor, M.D., Dr.Med. Center of Psychiatric Research, Aarhus University Hospital
University of Aarhus
November 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP