The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00801034
First received: December 2, 2008
Last updated: December 5, 2011
Last verified: December 2011

December 2, 2008
December 5, 2011
November 2008
November 2011   (final data collection date for primary outcome measure)
Effect on blood pressure [ Time Frame: three months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00801034 on ClinicalTrials.gov Archive Site
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Not Provided
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The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons
The Effects of Potassium on Physiological Variables in the Kidney and Cardiovascular Variables in Healthy Persons in a Double-blinded, Randomised, Placebo-controlled, Cross-over Study

In humans living of fruit and vegetables, hypertension is rarely seen. We wish to study if the development of hypertension has a connection to our intake of potassium. We know that fruit and vegetables contain a lot of potassium and we will simulate this intake by giving healthy subjects potassium as tablets.

Not Provided
Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Hypertension
  • Drug: Calcium
    tablets, 1 tablet 2 times per day in 28 days
  • Drug: Potassium
    Tablets, 5 tablets 2 times per day for 28 days
  • Placebo Comparator: 1
    Calcium tablets
    Intervention: Drug: Calcium
  • Active Comparator: 2
    Potassium tablets
    Intervention: Drug: Potassium
Matthesen SK, Larsen T, Vase H, Lauridsen TG, Pedersen EB. Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans. Scand J Clin Lab Invest. 2012 Feb;72(1):78-86. doi: 10.3109/00365513.2011.635216. Epub 2011 Dec 12.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
25
November 2011
November 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy
  • age 18-40 years old
  • BMI 18, 5-30
  • non-smoker

Exclusion Criteria:

  • daily use of medicine
  • alcohol or drugs
  • desire to become pregnant
  • not using safe anti-contraceptive
  • abnormal results in the initial testing
Both
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00801034
MED.RES.HOS.2008.01.SKM
Yes
Regional Hospital Holstebro
Regional Hospital Holstebro
Not Provided
Not Provided
Regional Hospital Holstebro
December 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP